Recombinant Human GRK5

• Cat.No.: GRK5-26369TH
• Product Overview: Recombinant full length GRK5 protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal enzyme tag, MW 95 kDa.

Specification

• Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
• Tissue specificity: Highest levels in heart, placenta, lung >skeletal muscle >brain, liver, pancreas >kidney.
• Biological activity: Specific Activity: >33 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 RGS domain.

Gene Information

• Gene Name: GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
• Official Symbol: GRK5
• Synonyms: GRK5; G protein-coupled receptor kinase 5; GPRK5
• Gene ID: 2869
• mRNA Refseq: NM_005308
• Protein Refseq: NP_005299
• MIM: 600870
• Uniprot ID: P34947
• Chromosome Location: 10q24-qter
• Pathway: Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem
• Function: ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; phospholipid binding; protein binding