Recombinant Human HRAS
Cat.No. : | HRAS-28759TH |
Product Overview : | Recombinant full length, proprietary tagged, Human H-Ras protein. 189 amino acids; Predicted MWt 47 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
Source : | E. coli |
Biological activity : | HRAS-28759TH is effective in activation of PI3K and PKB |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 5mM Magnesium chloride, 5mM Beta mercaptoethanol, 25mM Tris HCl, 150mM Sodium chloride, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Gene Name : | HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ] |
Official Symbol : | HRAS |
Synonyms : | HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; HRAS1; GTPase HRas; |
Gene ID : | 3265 |
mRNA Refseq : | NM_001130442 |
Protein Refseq : | NP_001123914 |
MIM : | 190020 |
Uniprot ID : | P01112 |
Chromosome Location : | 11p15.5 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Axon guidance, organism-specific biosystem; |
Function : | GTP binding; GTPase activity; Ral guanyl-nucleotide exchange factor activity; nucleotide binding; protein C-terminus binding; |
Products Types
◆ Recombinant Protein | ||
HRAS-2564R | Recombinant Rat HRAS Protein, His (Fc)-Avi-tagged | +Inquiry |
Hras-1169M | Recombinant Mouse Hras Protein, MYC/DDK-tagged | +Inquiry |
HRAS-85H | Active Recombinant Human HRAS Protein, His-tagged | +Inquiry |
HRAS-1962R | Recombinant Rhesus Macaque HRAS Protein, His (Fc)-Avi-tagged | +Inquiry |
HRAS-1284R | Recombinant Rat HRAS Protein (2-186 aa), His-tagged | +Inquiry |
◆ Lysates | ||
HRAS-556HCL | Recombinant Human HRAS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearch is ongoing, but there are emerging targeted therapies designed to address HRAS-related cancers.
Yes, genetic testing can identify HRAS mutations, aiding in the diagnosis and prognosis of certain disorders.
Yes, there is growing interest in exploring HRAS as a therapeutic target for non-cancerous diseases, such as cardiovascular disorders.
HRAS status can impact the response to certain cancer treatments, affecting the efficacy of targeted therapies and chemotherapy.
HRAS regulates the cell cycle by influencing the transition between different phases, ensuring proper cell division.
Customer Reviews (3)
Write a reviewWith their meticulous documentation and support, I am confident that my utilization of the HRAS protein in clinical trials will meet all necessary regulations and guidelines.
Their comprehensive certificates of analysis and safety data sheets serve as testaments to their commitment to ensuring the safety and integrity of their products.
Their ability to accommodate the requirements of large-scale experiments and guarantee a steady supply streamlines my research operations, eliminating any concerns related to prospective shortages.
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