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Recombinant Human HRAS

Cat.No. : HRAS-28759TH
Product Overview : Recombinant full length, proprietary tagged, Human H-Ras protein. 189 amino acids; Predicted MWt 47 kDa.
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  • Gene Information
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Description : This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Source : E. coli
Biological activity : HRAS-28759TH is effective in activation of PI3K and PKB
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 5mM Magnesium chloride, 5mM Beta mercaptoethanol, 25mM Tris HCl, 150mM Sodium chloride, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ]
Official Symbol : HRAS
Synonyms : HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; HRAS1; GTPase HRas;
Gene ID : 3265
mRNA Refseq : NM_001130442
Protein Refseq : NP_001123914
MIM : 190020
Uniprot ID : P01112
Chromosome Location : 11p15.5
Pathway : ARMS-mediated activation, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Axon guidance, organism-specific biosystem;
Function : GTP binding; GTPase activity; Ral guanyl-nucleotide exchange factor activity; nucleotide binding; protein C-terminus binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there targeted therapies specifically designed for HRAS-related cancers? 08/08/2022

Research is ongoing, but there are emerging targeted therapies designed to address HRAS-related cancers.

Can HRAS mutations be detected through genetic testing? 01/27/2019

Yes, genetic testing can identify HRAS mutations, aiding in the diagnosis and prognosis of certain disorders.

Can HRAS be a potential therapeutic target for non-cancerous diseases? 12/28/2018

Yes, there is growing interest in exploring HRAS as a therapeutic target for non-cancerous diseases, such as cardiovascular disorders.

How does HRAS influence the response to certain cancer treatments? 12/05/2018

HRAS status can impact the response to certain cancer treatments, affecting the efficacy of targeted therapies and chemotherapy.

How is HRAS involved in the regulation of the cell cycle? 03/18/2016

HRAS regulates the cell cycle by influencing the transition between different phases, ensuring proper cell division.

Customer Reviews (3)

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Reviews
08/15/2019

    With their meticulous documentation and support, I am confident that my utilization of the HRAS protein in clinical trials will meet all necessary regulations and guidelines.

    06/26/2019

      Their comprehensive certificates of analysis and safety data sheets serve as testaments to their commitment to ensuring the safety and integrity of their products.

      09/12/2018

        Their ability to accommodate the requirements of large-scale experiments and guarantee a steady supply streamlines my research operations, eliminating any concerns related to prospective shortages.

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