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Recombinant Human LDHB, His-tagged

Cat.No. : LDHB-26865TH
Product Overview : Recombinant full length protein, corresponding to amino acids 1-334 of Human lactate dehydrogenase B with N terminal His tag; 354 amino acids, 36.6kDa.
  • Specification
  • Gene Information
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Description : This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Protein length : 334 amino acids
Conjugation : HIS
Molecular Weight : 36.600kDa inclusive of tags
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSHMATLKEKLIAPVAEE EATVP NNKITVVGVGQVGMACAISILGKSL ADELALVDVLEDKLKGEMMDLQHGS LFLQTPKIVADKDYSVTANSKIVVV TAGVRQQEGESRLNLVQRNVNVFKF IIPQIVKYSPDCIIIVVSNPVDILT YVTWKLSGLPKHRVIGSGCNLDSAR FRYLMAEKLGIHPSSCHGWILGEHG DSSVAVWSGVNVAGVSLQELNPEMG TDNDSENWKEVHKMVVESAYEVIKL KGYTNWAIGLSVADLIESMLKNLSR IHPVSTMVKGMYGIENEVFLSLPCI LNARGLTSVINQKLKDDEVAQLKKS ADTLWDIQKDLKDL
Sequence Similarities : Belongs to the LDH/MDH superfamily. LDH family.
Gene Name : LDHB lactate dehydrogenase B [ Homo sapiens ]
Official Symbol : LDHB
Synonyms : LDHB; lactate dehydrogenase B; L-lactate dehydrogenase B chain;
Gene ID : 3945
mRNA Refseq : NM_001174097
Protein Refseq : NP_001167568
MIM : 150100
Uniprot ID : P07195
Chromosome Location : 12p12.2-p12.1
Pathway : Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Glycolysis and Gluconeogenesis, organism-specific biosystem;
Function : L-lactate dehydrogenase activity; NAD binding; identical protein binding; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Does LDHB play a role in heart disease? 03/08/2022

Yes, LDHB dysregulation is associated with heart conditions like myocardial infarction (heart attack) and heart failure.

Are there specific populations more susceptible to LDHB-related conditions? 10/12/2020

While LDHB-related diseases can affect anyone, some genetic predispositions may heighten the risk in certain ethnic groups.

How is LDHB protein clinically relevant? 01/14/2020

It plays a role in various physiological processes and has implications in disease states.

How does LDHB contribute to cancer? 09/07/2019

In certain cancers, elevated LDHB levels promote tumor growth by supporting the Warburg effect, where cancer cells use glycolysis even in the presence of oxygen.

Can LDHB be a therapeutic target in cancer treatment? 03/19/2016

Targeting LDHB shows promise in inhibiting cancer growth, and there's ongoing research in developing drugs that target this enzyme.

Customer Reviews (3)

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Reviews
04/27/2022

    I highly endorse the utilization of the LDHB Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.

    11/05/2020

      Their expertise has proven instrumental in overcoming obstacles and has greatly contributed to the success of my research endeavors.

      10/14/2016

        Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.

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