Recombinant Human LDHB, His-tagged
Cat.No. : | LDHB-26865TH |
Product Overview : | Recombinant full length protein, corresponding to amino acids 1-334 of Human lactate dehydrogenase B with N terminal His tag; 354 amino acids, 36.6kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Protein length : | 334 amino acids |
Conjugation : | HIS |
Molecular Weight : | 36.600kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSHMATLKEKLIAPVAEE EATVP NNKITVVGVGQVGMACAISILGKSL ADELALVDVLEDKLKGEMMDLQHGS LFLQTPKIVADKDYSVTANSKIVVV TAGVRQQEGESRLNLVQRNVNVFKF IIPQIVKYSPDCIIIVVSNPVDILT YVTWKLSGLPKHRVIGSGCNLDSAR FRYLMAEKLGIHPSSCHGWILGEHG DSSVAVWSGVNVAGVSLQELNPEMG TDNDSENWKEVHKMVVESAYEVIKL KGYTNWAIGLSVADLIESMLKNLSR IHPVSTMVKGMYGIENEVFLSLPCI LNARGLTSVINQKLKDDEVAQLKKS ADTLWDIQKDLKDL |
Sequence Similarities : | Belongs to the LDH/MDH superfamily. LDH family. |
Gene Name : | LDHB lactate dehydrogenase B [ Homo sapiens ] |
Official Symbol : | LDHB |
Synonyms : | LDHB; lactate dehydrogenase B; L-lactate dehydrogenase B chain; |
Gene ID : | 3945 |
mRNA Refseq : | NM_001174097 |
Protein Refseq : | NP_001167568 |
MIM : | 150100 |
Uniprot ID : | P07195 |
Chromosome Location : | 12p12.2-p12.1 |
Pathway : | Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Glycolysis and Gluconeogenesis, organism-specific biosystem; |
Function : | L-lactate dehydrogenase activity; NAD binding; identical protein binding; oxidoreductase activity; |
Products Types
◆ Recombinant Protein | ||
LDHB-3026R | Recombinant Rat LDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
LDHB-2309R | Recombinant Rhesus Macaque LDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
LDHB-424H | Recombinant Human LDHB Protein, MYC/DDK-tagged | +Inquiry |
Ldhb-1306M | Recombinant Mouse Ldhb Protein, MYC/DDK-tagged | +Inquiry |
LDHB-5021M | Recombinant Mouse LDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
LDH2-123H | Active Native Human Lactate Dehydrogenase 2 | +Inquiry |
LDH2-220H | Active Native Human Lactate Dehydrogenase 2 | +Inquiry |
◆ Lysates | ||
LDHB-4788HCL | Recombinant Human LDHB 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0510 | Lactate Dehydrogenase B (LDHB) Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, LDHB dysregulation is associated with heart conditions like myocardial infarction (heart attack) and heart failure.
While LDHB-related diseases can affect anyone, some genetic predispositions may heighten the risk in certain ethnic groups.
It plays a role in various physiological processes and has implications in disease states.
In certain cancers, elevated LDHB levels promote tumor growth by supporting the Warburg effect, where cancer cells use glycolysis even in the presence of oxygen.
Targeting LDHB shows promise in inhibiting cancer growth, and there's ongoing research in developing drugs that target this enzyme.
Customer Reviews (3)
Write a reviewI highly endorse the utilization of the LDHB Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.
Their expertise has proven instrumental in overcoming obstacles and has greatly contributed to the success of my research endeavors.
Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.
Ask a Question for All LDHB Products
Required fields are marked with *
My Review for All LDHB Products
Required fields are marked with *
Inquiry Basket