Recombinant Human MYL2, His-tagged

• Cat.No.: MYL2-28864TH
• Product Overview: Recombinant full length human Myosin Light Chain 2 protein, fused to His tag at N terminus; 186 amino acids, 20.9kDa.

Specification

• Description: Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 5mM Calcium chloride, 20mM Tris, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAPKKAKKRA GGANSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGVLKADYVR EMLTTQAERF SKEEVDQMFA AFPPDVTGNL DYKNLVHIITHGEEKD
• Sequence Similarities: Contains 3 EF-hand domains.

Gene Information

• Gene Name: MYL2 myosin, light chain 2, regulatory, cardiac, slow [ Homo sapiens ]
• Official Symbol: MYL2
• Synonyms: MYL2; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; cardiac ventricular myosin light chain 2; CMH10
• Gene ID: 4633
• mRNA Refseq: NM_000432
• Protein Refseq: NP_000423
• MIM: 160781
• Uniprot ID: P10916
• Chromosome Location: 12q24.11
• Pathway: CDC42 signaling events, organism-specific biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem
• Function: actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle

Reviews

04/09/2017

The MYL2 Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

11/02/2016

This protein has proven to be of great utility in protein electron microscopy structure analysis.

09/19/2016

Researchers utilizing the MYL2 Protein can rely on its robust and reproducible performance in a variety of experimental settings.

Q&As

Are there any gender or age-related differences in MYL2 protein expression in cardiac muscle?

Studies suggest that MYL2 expression levels may vary with age and gender, which could have implications for understanding cardiac health across different demographics.

Can MYL2 be used as a prognostic marker for predicting outcomes in cardiac patients?

Elevated MYL2 levels may be indicative of a poorer prognosis in certain cardiac conditions, providing valuable information for treatment planning.

What role does MYL2 play in personalized medicine for cardiac patients?

Understanding the genetic variations in MYL2 allows for personalized treatment strategies tailored to an individual's specific cardiac profile.

How does MYL2 contribute to the understanding of the molecular mechanisms underlying cardiac hypertrophy?

Dysregulation of MYL2 is implicated in hypertrophic cardiomyopathy, contributing to our understanding of the molecular pathways leading to cardiac hypertrophy.

How can MYL2 protein analysis aid in risk stratification for cardiovascular diseases?

Analyzing MYL2 variants and expression levels can help identify individuals at a higher risk of developing cardiac disorders, allowing for proactive management.