Native Human TTR


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Native Human TTR

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Cat.No. : TTR-31108TH
Product Overview : Full length Human Prealbumin purified from Human plasma; MWt 55kDa.
Description : This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Source : Human plasma
Species : Human
Form : Lyophilised:Please reconstitute with deionized water to the pre-lyophilization volume (lot specific).
Molecular Mass : 55kDa
Purity : >95% by SDS-PAGE
Storage : Shipped at 4°C . Store at -20°C .
Storage Buffer : Preservative: NoneConstituents: 50mM Sodium phosphate, 150mM Sodium chloride, pH 7.5
Gene Name : TTR transthyretin [ Homo sapiens ]
Official Symbol : TTR
Synonyms : TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin, amyloidosis type I; CTS; CTS1; PALB; TBPA;
Gene ID : 7276
mRNA Refseq : NM_000371
Protein Refseq : NP_000362
MIM : 176300
UniProt ID : P02766
Chromosome Location : 18q12.1
Pathway : Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;
Function : hormone activity; hormone binding; protein binding;

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