Native Human TTR

• Cat.No.: TTR-31108TH
• Product Overview: Full length Human Prealbumin purified from Human plasma; MWt 55kDa.

Specification

• Description: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
• Source: Human plasma
• Species: Human
• Form: Lyophilised:Please reconstitute with deionized water to the pre-lyophilization volume (lot specific).
• Molecular Mass: 55kDa
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C . Store at -20°C .
• Storage Buffer: Preservative: NoneConstituents: 50mM Sodium phosphate, 150mM Sodium chloride, pH 7.5

Gene Information

• Gene Name: TTR transthyretin [ Homo sapiens ]
• Official Symbol: TTR
• Synonyms: TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin, amyloidosis type I; CTS; CTS1; PALB; TBPA
• Gene ID: 7276
• mRNA Refseq: NM_000371
• Protein Refseq: NP_000362
• MIM: 176300
• UniProt ID: P02766
• Chromosome Location: 18q12.1
• Pathway: Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem
• Function: hormone activity; hormone binding; protein binding