|Official Full Name||transthyretin|
|Background||This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]|
|Synonyms||TTR; transthyretin; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ttr involved in several pathways and played different roles in them. We selected most pathways ttr participated on our site, such as Amyloid formation, Disease, Diseases associated with visual transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ttr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Amyloid formation||SEMG1; RHBDL1; APCS; TGFBI; HIST3H2BB; CEACAM21; TTR; CALCA; HIST4H4; ODAM|
|Disease||AP2S1; CDK8; CCDC59; GCKR; CCNC; TLR6; PACS1; RDBP; SFTPC; AP2M1|
|Diseases associated with visual transduction||OPN1MW; OPN1LW; STRA6; OPN1MW2; TTR; RBP4; OPN1SW; RLBP1; RBP1|
|Diseases of signal transduction||KREMEN1; LRRFIP1; CPSF6; OPN1LW; HEYL; HEY1; RBP4; JAG2; CUX1; HEY2|
|Extracellular matrix organization||PCOLCEB; COL9A1B; PCOLCE; CTRB1; BGNB; COL19A1; COL28A1; ABHD1; COL6A2; CTS7|
|FOXA2 and FOXA3 transcription factor networks||FOXA1; UCP2; CPT1A; CPT1C; DLK1; KCNJ11; CPT1B; CEBPA; TTR; FOXF1|
|Metabolism of proteins||EIF2B1; ST6GALNAC2; CNIH; EXOC1; PROZ; TOMM6; MTX1; DPH3; VBP1; TBCA|
|Non-integrin membrane-ECM interactions||TTR; TRAPPC4; DDR2; LAMC3; DMD; DDR1|
ttr has several biochemical functions, for example, hormone activity, hormone binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ttr itself. We selected most functions ttr had, and list some proteins which have the same functions with ttr. You can find most of the proteins on our site.
|hormone activity||METRNL; INSL5A; PTH; INHBC; GCGB; INSL3; PRL7A1; PRL2A1; PRL6A1; RETN|
|hormone binding||CALR; MC5R; LRP2; TTR; AMHR2; UCN2; ADIPOR1B; MC1R; GPR30; CRYM|
|identical protein binding||L3MBTL1; RIPK1; PUF60; RCAN1; KRTAP10-5; ABCD1; DYNLT1F; INHBA; STAT6; HOOK2|
|protein binding||C6orf211; MAB21L1; DSP; DOCK1; CD58; BAG4; OAS3; RAD51D; SNX20; LRSAM1|
|protein heterodimerization activity||H2AFX; MPP7; KCNA3; BCL2L2; HIST2H2AC; SLC51A; HIST1H2BL; HIST3H2BB; MICU1; BMP6|
ttr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ttr here. Most of them are supplied by our site. Hope this information will be useful for your research of ttr.
MT3; NECAB2; CDR2; AGER; IKBKAP; VIM