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Official Full Name transthyretin
Background This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
Synonyms TTR; transthyretin; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I;
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Guinea pig
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • Bovine Serum
    • E.coli
    • HEK293
    • Human Amniotic
    • Human Cell
    • Human Plasma
    • Mammalian Cell
    • Sheep Serum
    • Trichoplusia Ni Larval
    • Tag :
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TTR-3880H Recombinant Human TTR protein, His-tagged HEK293 His
    Mouse TTR-561M Recombinant Mouse TTR Protein, His-tagged HEK293 His
    Human TTR-11H Recombinant Human TTR Trichoplusia Ni Larval N/A
    Human TTR-131H Native Human Prealbumin protein Human Amniotic N/A
    Human TTR-1837H Recombinant Human Transthyretin E.coli N/A
    Human TTR-2149HCL Recombinant Human TTR cell lysate Human Cell N/A
    Human TTR-21H Human Prealbumin Reference Standard N/A
    Human TTR-254H Native Human Prealbumin Human Plasma N/A
    Human TTR-291H Recombinant Human TTR Protein, His-tagged E.coli His
    Human TTR-2922H Recombinant Human TTR Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TTR-30616TH Recombinant Human TTR E.coli N/A
    Human TTR-31108TH Native Human TTR Human plasma N/A
    Human TTR-31110TH Recombinant Human TTR E.coli N/A
    Human TTR-31111TH Recombinant Human TTR N/A
    Human TTR-3950H Recombinant Human TTR, His tagged Human Cell His
    Human TTR-706H Native Human Transthyretin Human Plasma N/A
    Human TTR-728H Recombinant Human TTR protein, His-tagged E.coli His
    Mouse Ttr-1392M Recombinant Mouse Ttr Protein E.coli N/A
    Mouse TTR-17603M Recombinant Mouse TTR Protein Mammalian Cell His
    Mouse Ttr-54M Mouse Prealbumin Reference Standard N/A
    Mouse Ttr-729M Recombinant Mouse Ttr protein, His-tagged E.coli His
    Rat TTR-6352R Recombinant Rat TTR Protein Mammalian Cell His
    Rat Ttr-731R Recombinant Rat Ttr protein, His-tagged E.coli His
    Rat Ttr-88R Rat Prealbumin Reference Standard N/A
    Cynomolgus Monkey TTR-1059C Recombinant Cynomolgus TTR Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TTR-5023R Recombinant Rhesus monkey TTR Protein, His-tagged Mammalian Cell His
    Dog TTR-725D Recombinant Dog TTR protein, His & T7-tagged E.coli His/T7
    Bovine TTR-155B Native Bovine Prealbumin protein Bovine Serum N/A
    Chicken TTR-5421C Recombinant Chicken TTR Mammalian Cell His
    Chicken TTR-726C Recombinant Chicken TTR protein, His-tagged E.coli His
    Rabbit TTR-732R Recombinant Rabbit TTR protein, His & T7-tagged E.coli His/T7
    Zebrafish TTR-1438Z Recombinant Zebrafish TTR Mammalian Cell His
    Sheep TTR-141S Native Sheep prealbumin Sheep Serum N/A
    Cattle TTR-724C Recombinant Cattle TTR protein, His-tagged E.coli His
    Guinea pig Ttr-727G Recombinant Guinea pig Ttr protein, His & T7-tagged E.coli His/T7
    Pig TTR-730P Recombinant Pig TTR protein, His & T7-tagged E.coli His/T7

    ttr involved in several pathways and played different roles in them. We selected most pathways ttr participated on our site, such as Amyloid formation, Disease, Diseases associated with visual transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ttr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease AP2S1; CDK8; CCDC59; GCKR; CCNC; TLR6; PACS1; RDBP; SFTPC; AP2M1
    Diseases associated with visual transduction OPN1MW; OPN1LW; STRA6; OPN1MW2; TTR; RBP4; OPN1SW; RLBP1; RBP1
    Diseases of signal transduction KREMEN1; LRRFIP1; CPSF6; OPN1LW; HEYL; HEY1; RBP4; JAG2; CUX1; HEY2
    Extracellular matrix organization PCOLCEB; COL9A1B; PCOLCE; CTRB1; BGNB; COL19A1; COL28A1; ABHD1; COL6A2; CTS7
    FOXA2 and FOXA3 transcription factor networks FOXA1; UCP2; CPT1A; CPT1C; DLK1; KCNJ11; CPT1B; CEBPA; TTR; FOXF1
    Metabolism of proteins EIF2B1; ST6GALNAC2; CNIH; EXOC1; PROZ; TOMM6; MTX1; DPH3; VBP1; TBCA
    Non-integrin membrane-ECM interactions TTR; TRAPPC4; DDR2; LAMC3; DMD; DDR1

    ttr has several biochemical functions, for example, hormone activity, hormone binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ttr itself. We selected most functions ttr had, and list some proteins which have the same functions with ttr. You can find most of the proteins on our site.

    Function Related Protein
    hormone activity METRNL; INSL5A; PTH; INHBC; GCGB; INSL3; PRL7A1; PRL2A1; PRL6A1; RETN
    hormone binding CALR; MC5R; LRP2; TTR; AMHR2; UCN2; ADIPOR1B; MC1R; GPR30; CRYM
    identical protein binding L3MBTL1; RIPK1; PUF60; RCAN1; KRTAP10-5; ABCD1; DYNLT1F; INHBA; STAT6; HOOK2
    protein binding C6orf211; MAB21L1; DSP; DOCK1; CD58; BAG4; OAS3; RAD51D; SNX20; LRSAM1
    protein heterodimerization activity H2AFX; MPP7; KCNA3; BCL2L2; HIST2H2AC; SLC51A; HIST1H2BL; HIST3H2BB; MICU1; BMP6

    ttr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ttr here. Most of them are supplied by our site. Hope this information will be useful for your research of ttr.


    Haussecker, D; et al. Current issues of RNAi therapeutics delivery and development. JOURNAL OF CONTROLLED RELEASE 195:49-54(2014).
    Obici, L; Merlini, G; et al. An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1239-1251(2014).

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