TTR
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Official Full Name
transthyretin
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Overview
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] -
Synonyms
TTR; transthyretin; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
- Bovine
- Cattle
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus Monkey
- Dog
- Guinea pig
- Human
- Macaca Fascicularis
- Mouse
- Pig
- Pongo pygmaeus abelii
- Rabbit
- Rat
- Rhesus monkey
- Sheep
- Zebrafish
- Bovine Serum
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Amniotic
- Human Cell
- Human plasma
- Human Plasma
- Mammalian Cell
- Mammalian cells
- Sheep Serum
- Trichoplusia Ni Larval
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- His|T7
- SUMO
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | TTR-30616TH | Recombinant Human TTR | E.coli | N/A | ||
Human | TTR-291H | Recombinant Human TTR Protein, His-tagged | E.coli | His | ||
Human | TTR-1837H | Recombinant Human Transthyretin | E.coli | N/A | ||
Human | TTR-31110TH | Recombinant Human TTR | E.coli | N/A | ||
Human | TTR-3950H | Recombinant Human TTR protein, His-tagged | HEK293 | His | Gly21-Glu147 | |
Human | TTR-31111TH | Recombinant Human TTR | N/A | |||
Human | TTR-11H | Recombinant Human TTR | Trichoplusia Ni Larval | N/A | ||
Human | TTR-728H | Recombinant Human TTR protein, His-tagged | E.coli | His | Gly21~Glu147 | |
Human | TTR-2149HCL | Recombinant Human TTR cell lysate | Human Cell | N/A | ||
Human | TTR-254H | Native Human Prealbumin | Human Plasma | N/A | ||
Human | TTR-2774H | Recombinant Human TTR Protein, His-tagged | E.coli | N-His | Met1-Val105 | |
Human | TTR-3880H | Recombinant Human TTR protein, His-tagged | HEK293 | His | Gly21-Glu147 | |
Human | TTR-131H | Native Human Prealbumin protein | Human Amniotic | N/A | Full length native Human Prealbumin | |
Human | TTR-31108TH | Native Human TTR | Human plasma | N/A | ||
Human | TTR-1220HFL | Recombinant Full Length Human TTR Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | TTR-6215H | Recombinant Human TTR Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | TTR-706H | Native Human Transthyretin | Human Plasma | N/A | ||
Human | TTR-128H | Recombinant Human TTR Protein, His-tagged | E.coli | His | ||
Human | TTR-2922H | Recombinant Human TTR Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | TTR-072H | Recombinant Human TTR Protein | HEK293 | 147 | ||
Human | TTR-2273H | Recombinant Human TTR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | TTR-2530H | Recombinant Human TTR protein(31-130 aa), C-His-tagged | E. coli | C-His | 31-130 aa | |
Human | TTR-1284H | Recombinant Human TTR protein, His-tagged | HEK293 | His | Gly 21 - Glu 147 | |
Human | TTR-2273H-B | Recombinant Human TTR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | TTR-04H | Recombinant Human TTR (L55P) Protein (Full Length) | E.coli | Full Length | ||
Human | TTR-21H | Human Prealbumin Reference Standard | N/A | |||
Human | TTR-129H | Recombinant Human TTR Protein, His-tagged | E.coli | His | ||
Mouse | Ttr-729M | Recombinant Mouse Ttr protein, His-tagged | E.coli | His | Gly21~Asn147 | |
Mouse | TTR-17603M | Recombinant Mouse TTR Protein | Mammalian Cell | His | ||
Mouse | Ttr-1392M | Recombinant Mouse Ttr Protein | E.coli | N/A | ||
Mouse | TTR-9747M-B | Recombinant Mouse TTR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | TTR-561M | Recombinant Mouse TTR protein, His-tagged | HEK293 | His | Met1-Asn147 | |
Mouse | Ttr-54M | Mouse Prealbumin Reference Standard | N/A | |||
Mouse | Ttr-3631M | Recombinant Mouse Ttr protein, His-SUMO-tagged | E.coli | His-SUMO | 23-147aa | |
Mouse | Ttr-6725M | Recombinant Mouse Ttr Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | TTR-9747M | Recombinant Mouse TTR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Ttr-3630M | Recombinant Mouse Ttr protein, His-SUMO-tagged | E.coli | His-SUMO | 21-147aa | |
Mouse | Ttr-1240M | Recombinant Mouse Ttr protein, His-tagged | Yeast | His | 23-147aa | |
Mouse | Ttr-3632M | Recombinant Mouse Ttr protein, GST-tagged | E.coli | GST | 23-147aa | |
Mouse | Ttr-5542M | Recombinant Mouse Ttr protein, His-tagged | Yeast | His | 21-147aa | |
Rat | TTR-6352R | Recombinant Rat TTR Protein | Mammalian Cell | His | ||
Rat | Ttr-731R | Recombinant Rat Ttr protein, His-tagged | E.coli | His | Ala20~Asn147 | |
Rat | TTR-6008R-B | Recombinant Rat TTR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | TTR-6008R | Recombinant Rat TTR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Ttr-88R | Rat Prealbumin Reference Standard | N/A | |||
Rhesus monkey | TTR-5023R | Recombinant Rhesus monkey TTR protein, His-Myc-tagged | HEK293 | His/Myc | 21-147aa | |
Rabbit | TTR-732R | Recombinant Rabbit TTR protein, His & T7-tagged | E.coli | His/T7 | Pro22~Glu147 (Accession # P07489) | |
Dog | TTR-725D | Recombinant Dog TTR protein, His & T7-tagged | E.coli | His/T7 | Ala23~Glu147 (Accession # E2R5U8) | |
Bovine | TTR-155B | Native Bovine Prealbumin protein | Bovine Serum | N/A | Full length native Bovine Prealbumin protein | |
Cattle | TTR-724C | Recombinant Cattle TTR protein, His-tagged | E.coli | His | Ser22~Ala147 (Accession # O46375) | |
Cynomolgus | TTR-1059C | Recombinant Cynomolgus TTR Protein, His-tagged | HEK293 | His | ||
Cynomolgus monkey | TTR-3633C | Recombinant Cynomolgus monkey TTR protein, His-tagged | E.coli | His | 21-147aa | |
Cynomolgus monkey | TTR-5077C | Recombinant Cynomolgus monkey TTR protein, His-tagged | HEK293 | His | 21-147aa | |
Cynomolgus Monkey | TTR-802C | Recombinant Cynomolgus Monkey TTR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | TTR-802C-B | Recombinant Cynomolgus Monkey TTR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Guinea pig | Ttr-727G | Recombinant Guinea pig Ttr protein, His & T7-tagged | E.coli | His/T7 | Met12~Ala126 (Accession# H0VMD5) | |
Macaca Fascicularis | TTR-01H | Recombinant Cynomolgus TTR Protein, His-tagged | HEK293 | His | 133 | |
Pongo pygmaeus abelii | TTR-3771P | Recombinant Pongo pygmaeus abelii TTR protein, His-SUMO-tagged | E.coli | His-SUMO | 21-147aa | |
Sheep | TTR-141S | Native Sheep prealbumin | Sheep Serum | N/A | Full length native Sheep prealbumin | |
Zebrafish | TTR-1438Z | Recombinant Zebrafish TTR | Mammalian Cell | His | ||
Zebrafish | TTR-3667Z | Recombinant Zebrafish TTR protein, His-tagged | E.coli | His | 20-149aa | |
Pig | TTR-730P | Recombinant Pig TTR protein, His & T7-tagged | E.coli | His/T7 | Gly21~Leu150 (Accession # P50390) | |
Chicken | TTR-726C | Recombinant Chicken TTR protein, His-tagged | E.coli | His | Ala21~Glu150 (Accession # P27731) | |
Chicken | TTR-5421C | Recombinant Chicken TTR | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TTR Related Articles
- TTR Related Research Area
TTR involved in several pathways and played different roles in them. We selected most pathways TTR participated on our site, such as Amyloid formation, Disease, Diseases associated with visual transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Amyloid formation | CST3;HIST4H4;TTR;LTF;CEACAM21;HIST2H3C;TGFBI;RHBDL1;SEMG1 |
Disease | MIB1;CFTR;CTBP2;IPO5;TTR;APOBEC3G;ANTXR2;FDXR;TH1L |
Diseases associated with visual transduction | RBP1;OPN1MW;STRA6;RLBP1;RBP4;OPN1MW2;TTR;OPN1SW;OPN1LW |
Diseases of signal transduction | FGFR1OP2;KREMEN1;FKBP1A;TTR;CDK8;DERL2;HEYL;RNF43;OS9 |
Extracellular matrix organization | COL8A1A;COL4A5;SERPINH1B;MMP10;SPARC;PCOLCEA;COL5A3B;CEACAM8;SERPINH1 |
FOXA2 and FOXA3 transcription factor networks | CEBPA;TTR;KCNJ11;CPT1B;DLK1;CPT1C;FOXF1;FOXA1;UCP2 |
Metabolism of proteins | MGAT4A;BCHE;CCT6A;PAPPAB;TRAPPC2;NANP;MPDU1B;RNF2;DAD1 |
Non-integrin membrane-ECM interactions | LAMC3;DDR2;TRAPPC4;DDR1;DMD;TTR |
TTR has several biochemical functions, for example, hormone activity, hormone binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTR itself. We selected most functions TTR had, and list some proteins which have the same functions with TTR. You can find most of the proteins on our site.
Function | Related Protein |
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hormone activity | PRL7C1;URP2;PRL2A1;INSL4;GUCA2A;PPY;INS1;PTHLHA;GNRH3 |
hormone binding | MC1R;TTR;CALR;LRP2;NPR3;ADIPOR1A;CRYM;NPR2;NPR1 |
identical protein binding | EPOR;DVL1;DPY30;TGFB3;GSTM3;VWA2;TNK2;CAV1;IL12B |
protein binding | BFSP2;COX8A;ADAM10;PRDX6;KIFAP3;CALM2;UNC119B;STOML2;LMO4 |
protein heterodimerization activity | SYT16;HSPD1;HIST1H2BF;AGTR1;CREB3L3;CLCN3;AXL;HIST1H4K;MYO5A |
TTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTR here. Most of them are supplied by our site. Hope this information will be useful for your research of TTR.
MT3; NECAB2; CDR2; AGER; IKBKAP; VIM
- Q&As
- Reviews
Q&As (5)
Ask a questionTTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.
RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.
TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.
TTR is mainly synthesized in the liver.
TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.
Customer Reviews (3)
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