Recombinant Human metallopeptidase inhibitor 1, His-tagged
Cat.No. : | TIMP1-287H |
Product Overview : | Recombinant Human TIMP-1 comprises a 184 amino acid fragment (24-207) corresponding to the mature TIMP-1 protein and is expressed inE. coliwith an aminoterminal hexahistidine tag. |
- Specification
- Gene Information
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Cat. No. : | TIMP1-287H |
Description : | TIMP-1 is an inducible glycoprotein, which is synthesized by many different cell types. TIMP-1 binds in a reversible fashion to matrix metalloproteinases, with regions in the N-terminal domain binding to the MMP substrate-binding site. TIMP-1 also functions as erthyroid-potentiating activity via translocation to the nucleus and also in inhibiting apoptosis in B-cells. |
Source : | E.coli. |
Purity : | >95% by SDS-PAGE |
Form : | Liquid |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Gene Name : | TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ] |
Synonyms : | CLGI; EPA, EPO; HCI; TIMP; Erythroid-potentiating activity; tissue inhibitor of metalloprotease 1; collagenase inhibitor; metalloprotease inhibitor 1 precursor; tissue inhibitor of metalloproteases; FLJ90373; OTTHUMP00000023214; TIMP-1; Collagenase inhibitor; Erythroid-potentiating activity; TIMP metallopeptidase inhibitor 1; erythroid potentiating activity; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor. |
Gene ID : | 7076 |
mRNA Refseq : | NM_003254 |
Protein Refseq : | NP_003245 |
MIM : | 305370 |
UniProt ID : | P01033 |
Chromosome Location : | Xp11.3-p11.23 |
Function : | enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protein binding |
Products Types
◆ Recombinant Protein | ||
TIMP1-0058H | Recombinant Human TIMP1 Protein | +Inquiry |
TIMP1-4536R | Recombinant Rhesus Macaque TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Timp1-410R | Recombinant Rat Timp1 Protein, His-tagged | +Inquiry |
Timp1-01M | Recombinant Mouse Timp1 Protein, His-tagged | +Inquiry |
TIMP1-5733R | Recombinant Rat TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
TIMP1-91B | Active Native Bovine Thrombin | +Inquiry |
TIMP1-30840TH | Native Human TIMP1 | +Inquiry |
TIMP1-92H | Native Human TIMP-1 | +Inquiry |
◆ Lysates | ||
TIMP1-1490RCL | Recombinant Rat TIMP1 cell lysate | +Inquiry |
TIMP1-2376MCL | Recombinant Mouse TIMP1 cell lysate | +Inquiry |
TIMP1-2678HCL | Recombinant Human TIMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.
TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.
FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.
TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.
TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.
Customer Reviews (3)
Write a reviewThe efficient delivery of this product ensured that our research timelines were met without any complications.
Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.
This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.
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