Recombinant Human FLT1, His-tagged
Cat.No. : | FLT1-544H |
Product Overview : | Recombinant human FLT1 was expressed by baculovirus inSf9 cells usingan N-terminal His tag. MW=67.5kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FLT1-544H |
Description : | FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS. The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers. In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing. Both the full length and soluble form of FLT1 show strong binding affinity for VEGF. |
Source : | Baculovirus infected Sf9 cells. |
Purity : | >70% by SDS-PAGE. |
Specific Activity : | 170 U/mg. One unit is defined as the amount of enzyme that will transfer 1 nmol phosphate to the tyrosine substrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 uM Na-orthovanadate, 0.1 mM ATP, 30 ug/ml Poly (Glu:Tyr)4:1 substrate, and 2 ug /ml recombinant Flt1. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. |
Stability : | >6 months at –80°C. |
Gene Name : | FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [ Homo sapiens ] |
Synonyms : | FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; VEGFR1; vascular endothelial growth factor receptor 1; EC 2.7.10.1; VEGFR-1; Vascular permeability factor receptor; Flt-1; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT |
Gene ID : | 2321 |
mRNA Refseq : | NM_001159920 |
Protein Refseq : | NP_001153392 |
MIM : | 165070 |
UniProt ID : | P17948 |
Chromosome Location : | 13q12 |
Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Signaling by VEGF |
Function : | ATP binding; growth factor binding; identical protein binding; nucleotide binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
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FLT1-3810H | Active Recombinant Human FLT1 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
FLT1-2020R | Recombinant Rat FLT1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FLT1-1314H | Recombinant Human FLT1 Protein (P801-L1158), His tagged | +Inquiry |
◆ Lysates | ||
FLT1-1909HCL | Recombinant Human FLT1 cell lysate | +Inquiry |
FLT1-1207RCL | Recombinant Rat FLT1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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