| Cat. No. : | CSF3R-3120H |
| Product Overview : | Recombinant Human CSF3R (extracellular domain, Met 1-Pro 621) with five aminio acids at the C-terminus, was expressed in Human cells. |
| Description : | Granulocyte Colony Stimulating Factor Receptor (G-CSFR) which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. G-CSFR mediates the specific effect of G-CSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. |
| Purity : | >95% as determined by SDS-PAGE. |
| Endotoxin : | < 1.0 EU per 1μg of the protein as determined by the LAL method. |
| Stability : | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Predicted N terminal : | Glu 25 |
| Molecular Mass : | The mature recombinant human G-CSFR consists of 63 amino acids and predicts a molecular mass of 69.0 KDa. As a result of glycosylation, the apparent molecular mass of rhG-CSFR is approximately 90-95KDa in SDS-PAGE under reducing conditions. |
| Formulation : | Lyophilized from sterile PBS, pH 7.4 . Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Storage : | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles. |
| Gene Name : | CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ] |
| Synonyms : | colony stimulating factor 3 receptor (granulocyte); GCSFR; colony stimulating factor 3 receptor; antigenOTTHUMP00000009703; CSF3R; antigenOTTHUMP00000009704; CD114; antigenOTTHUMP00000009705; granulocyte colony stimulating factor receptor |
| Gene ID : | 1441 |
| mRNA Refseq : | NM_000760 |
| Protein Refseq : | NP_000751 |
| MIM : | 138971 |
| UniProt ID : | Q99062 |
| Chromosome Location : | 1p35-p34.3 |
| Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer |
| Function : | cytokine receptor activity; otein binding; receptor activity |
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