Active Recombinant Human CSF3R Protein, His&Avi tagged

• Cat.No.: CSF3R-68H
• Product Overview: GCSFR dimer protein contains a GCSFR extracellular domain (UniProt# Q99062) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 25-627 aa
• Description: Human granulocyte colony-stimulating factor receptor (GCSFR) is a transmembrane receptor and a member of the Type I cytokine receptor family. GCSFR is also known as G-CSF-R, cluster of differentiation 114 (CD114), CSF3R, colony stimulating factor 3 receptor, and SCN7. GCSFR contains an extracellular domain with an immunoglobulin-like (Ig-like) domain, a cytokine receptor homologous domain, and three fibronectin type III domains followed by a transmembrane domain, and cytoplasmic domain. GCSFR is a cell-surface receptor for granulocyte colony-stimulating factor (GCSF) and is expressed on precursor cells in the bone marrow. It exists as a monomer, pre-formed dimer, ligand-induced dimer, and ligand independent dimer. GCSFR’s dimerization is crucial for its functions in both physiological and pathological status. Increased GCSFR expression has been shown in a variety of cancers and is related to tumor proliferation, migration, and metastasis. GCSFR is an emerging target of cancer therapeutics.
• Molecular Mass: 154 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for GCSFR-specific antibody and granulocyte colony-stimulating factor (GCSF) ligand protein binding assays. Suggested Applications: ELISA for GCSFR-specific antibody and granulocyte colony-stimulating factor (GCSF) ligand protein binding assays. SPR & BLI for GCSFR-specific antibody and GCSF protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene ID: 1441
• Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [Homo sapiens (human)]
• Official Symbol: CSF3R
• Synonyms: CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; granulocyte colony-stimulating factor receptor; GCSFR; G-CSF-R; CD114 antigen; G-CSF receptor
• mRNA Refseq: NM_000760
• Protein Refseq: NP_000751
• MIM: 138971
• UniProt ID: Q99062