Cat.No. :	TNFRSF11B-20H
Description :	Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.
Species :	Human
Form :	Liquid
Bio-activity :	The level of Osteoprotegrin in the serum was quantified using ELISA.
Usage :	For research use only, not for diagnostic or therapeutic use.
Quality Control Test :	Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.
Storage :	Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days.
Concentration :	13.19 ng/ml
Preservative :	0.1% sodium azide

Gene Name :	TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [ Homo sapiens ]
Official Symbol :	TNFRSF11B
Synonyms :	TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG, osteoprotegerin; tumor necrosis factor receptor superfamily member 11B; OCIF; TR1; osteoprotegerin; osteoclastogenesis inhibitory factor; OPG; MGC29565;
Gene ID :	4982
mRNA Refseq :	NM_002546
Protein Refseq :	NP_002537
MIM :	602643
UniProt ID :	O00300
Chromosome Location :	8q24
Pathway :	Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Monoamine Transport, organism-specific biosystem; Osteoblast Signaling, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
Function :	binding; cytokine activity; receptor activity;

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