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Human Osteoprotegrin Reference Standard
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Cat.No. : | TNFRSF11B-20H |
Description : | Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis. |
Species : | Human |
Form : | Liquid |
Bio-activity : | The level of Osteoprotegrin in the serum was quantified using ELISA. |
Usage : | For research use only, not for diagnostic or therapeutic use. |
Quality Control Test : | Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C. |
Storage : | Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days. |
Concentration : | 13.19 ng/ml |
Preservative : | 0.1% sodium azide |
Gene Name : | TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [ Homo sapiens ] |
Official Symbol : | TNFRSF11B |
Synonyms : | TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG, osteoprotegerin; tumor necrosis factor receptor superfamily member 11B; OCIF; TR1; osteoprotegerin; osteoclastogenesis inhibitory factor; OPG; MGC29565; |
Gene ID : | 4982 |
mRNA Refseq : | NM_002546 |
Protein Refseq : | NP_002537 |
MIM : | 602643 |
UniProt ID : | O00300 |
Chromosome Location : | 8q24 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Monoamine Transport, organism-specific biosystem; Osteoblast Signaling, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; |
Function : | binding; cytokine activity; receptor activity; |
◆ Recombinant Protein
TNFRSF11B-365H | Recombinant Human TNFRSF11B Protein (Met1-Leu401), HIgG1 Fc-tagged | +Inquiry |
Tnfrsf11b-70M | Recombinant Mouse Tnfrsf11b Protein, His-tagged | +Inquiry |
TNFRSF11B-169H | Recombinant Human TNFRSF11B,His-tagged | +Inquiry |
TNFRSF11B-4141H | Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b | +Inquiry |
TNFRSF11B-152H | Recombinant Human tumor necrosis factor receptor superfamily, member 11b, HIgG1 Fc-tagged | +Inquiry |
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◆ Native Protein
TNFRSF11B-54H | Native Human Osteoprotegerin | +Inquiry |
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◆ Lysates
TNFRSF11B-1183CCL | Recombinant Cynomolgus TNFRSF11B cell lysate | +Inquiry |
TNFRSF11B-2176HCL | Recombinant Human TNFRSF11B cell lysate | +Inquiry |
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TNFRSF10ATnfrsf10bTNFRSF10CTNFRSF10DTNFRSF11ATNFRSF11BTnfrsf12aTNFRSF13BTNFRSF13CTNFRSF14Tnfrsf17Tnfrsf18Tnfrsf19TNFRSF1ATNFRSF1BTNFRSF21Tnfrsf22Tnfrsf23TNFRSF25Tnfrsf26TNFRSF4TNFRSF6BTNFRSF8TNFRSF9TNFRSF12
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