PCSK9(D374T)-LDLR TR-FRET Assay Kit
Cat.No. : | Kit-1806 |
Product Overview : | PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. The D374T mutation results in higher affinity of PCSK9 for LDLR. |
- Specification
- Gene Information
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Size : | 384 reactions |
Applications : | Great for screening small molecular inhibitors for drug discovery and HTS applications. |
Storage : | At least 6 months from date of receipt when stored as directed. |
Products Types
◆ Recombinant Protein | ||
PCSK9-02H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-33H | Recombinant Human PCSK9 Protein, C-AVI tagged, Biotinylated | +Inquiry |
PCSK9-414R | Recombinant Rhesus macaque PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-005H | Active Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-408H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-0665 | PCSK9-BIRC2 in vitro Binding Assay Kit | +Inquiry |
Kit-0666 | PCSK9-LDLR in vitro Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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