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PCSK9(D374T)-LDLR TR-FRET Assay Kit
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Cat.No. : | Kit-1806 |
Product Overview : | PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. The D374T mutation results in higher affinity of PCSK9 for LDLR. |
Size : | 384 reactions |
Applications : | Great for screening small molecular inhibitors for drug discovery and HTS applications. |
Storage : | At least 6 months from date of receipt when stored as directed. |
◆ Recombinant Protein
PCSK9-812M | Recombinant Mouse PCSK9 Protein (Met1-Gln694), MlgG1 Fc-tagged | +Inquiry |
Pcsk9-020M | Recombinant Mouse Pcsk9 Protein, MYC/DDK-tagged | +Inquiry |
PCSK9-86H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-005H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-352H | Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated | +Inquiry |
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◆ Lysates
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
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◆ Assay kits
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
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