Active Recombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated

Cat.No. : Pcsk9-209M
Product Overview : Biotinylated Mouse PCSK9 is expressed from HEK293 cells. It contains AA Gln 35 - Gln 694 (Accession # AAH38085.1). This protein carries an Avi tag at the C-terminus, followed by a polyhistidine tag.
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Source : HEK293
Species : Mouse
Tag : His-Avi
Predicted N Terminal : Gln 35
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Bio-activity : Immobilized Mouse LDL R, His Tag at 10 ug/mL (100 uL/well) can bind Biotinylated Mouse PCSK9, His Tag with a linear range of 2-16 ug/mL.
Molecular Mass : The protein has a calculated MW of 74.9 kDa. The protein migrates as 20 kDa and 65 kDa on a SDS-PAGE gel under reducing condition due to glycosylation and proteolytic digestion.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Characteristic : Biotinylation of this product is performed using Avitag technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : For long term storage, the product should be stored at lyophilized state at -20ºC or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8ºC for 12 months in lyophilized state; -70ºC for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Pcsk9 proprotein convertase subtilisin/kexin type 9 [ Mus musculus ]
Official Symbol : Pcsk9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; NARC-1; convertase subtilisin; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; FH3; PC9; Narc1; HCHOLA3; AI415265; AI747682; MGC47409;
Gene ID : 100102
mRNA Refseq : NM_153565
Protein Refseq : NP_705793

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
11/13/2022

    In immunological experiments, it was found that it had good antigenicity and could induce target immune responses.

    07/07/2022

      It promoted cell growth and proliferation.

      03/04/2022

        High catalytic efficiency.

        Q&As (6)

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        Is there a relationship between genetic mutations in the PCSK9 protein and cardiovascular disease? 12/30/2019

        Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.

        How can PCSK9 protein be used for vaccine development? 12/17/2019

        PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.

        What is the relationship between PCSK9 protein and obesity? 07/23/2019

        This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.

        What are the new prospects for future therapies that inhibit PCSK9 protein? 06/26/2019

        Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.

        What drugs are currently available to inhibit the PCSK9 protein? 05/08/2019

        Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.

        What is the relationship between PCSK9 protein and hypercholesterolemia? 01/11/2019

        PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.

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