IL17RA-153H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Active Human IL17RA Protein (ECD) with His tag (C-ter) was expressed in HEK293.
Description :
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Source :
HEK293
Species :
Human
Tag :
His(C-ter)
Form :
Powder
Bio-activity :
Measured by its ability to inhibit IL-17A induced IL-6 secretion by HeLa cells. The ED50 for this effect is 0.02-0.1 μg/mL in the presence of 10 ng/mL recombinant human IL-17A.
Protein Length :
Leu33-Trp320
Endotoxin :
Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity :
> 95% (by SDS-PAGE)
Applications :
Binding, FuncSt, SDS-PAGE
Notes :
For laboratory research only, not for drug, diagnostic or other use.
Storage :
Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer :
PBS (pH 7.4)
Reconstitution :
Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.