Recombinant Active Human IL17RA Protein (ECD), His-tagged(C-ter)
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Cat.No. : | IL17RA-153H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Active Human IL17RA Protein (ECD) with His tag (C-ter) was expressed in HEK293. |
Description : | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
Source : | HEK293 |
Species : | Human |
Tag : | His(C-ter) |
Form : | Powder |
Bio-activity : | Measured by its ability to inhibit IL-17A induced IL-6 secretion by HeLa cells. The ED50 for this effect is 0.02-0.1 μg/mL in the presence of 10 ng/mL recombinant human IL-17A. |
Protein Length : | Leu33-Trp320 |
Endotoxin : | Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test. |
Purity : | > 95% (by SDS-PAGE) |
Applications : | Binding, FuncSt, SDS-PAGE |
Notes : | For laboratory research only, not for drug, diagnostic or other use. |
Storage : | Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Storage Buffer : | PBS (pH 7.4) |
Reconstitution : | Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water. |
SDS-PAGE : |
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Gene Name : | IL17RA interleukin 17 receptor A [ Homo sapiens ] |
Official Symbol : | IL17RA |
Synonyms : | IL17RA; interleukin 17 receptor A; IL17R, interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262; |
Gene ID : | 23765 |
mRNA Refseq : | NM_014339 |
Protein Refseq : | NP_055154 |
MIM : | 605461 |
UniProt ID : | Q96F46 |
◆ Recombinant Protein
IL17RA-4873H | Recombinant Human IL17RA Protein, Fc/His-tagged | +Inquiry |
IL17RA-450H | Recombinant Human IL17RA Protein (Met1-Trp320), His-tagged, Biotinylated | +Inquiry |
IL17RA-442R | Recombinant Rhesus IL17RA Protein, His-tagged | +Inquiry |
Il17ra-1240M | Recombinant Mouse Il17ra Protein, MYC/DDK-tagged | +Inquiry |
IL17RA-449H | Recombinant Human IL17RA Protein (Met1-Trp320), His-Fc-tagged, Biotinylated | +Inquiry |
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◆ Lysates
IL17RA-1441RCL | Recombinant Rat IL17RA cell lysate | +Inquiry |
IL17RA-1070MCL | Recombinant Mouse IL17RA cell lysate | +Inquiry |
IL17RA-1252CCL | Recombinant Cynomolgus IL17RA cell lysate | +Inquiry |
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