IL17RA
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Official Full Name
interleukin 17 receptor A
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Background
Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the;maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin;17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A.;Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as;rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. -
Synonyms
CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R; interleukin-17 receptor A; IL-17 receptor A; Brodalumab; 1174395-19-7; Ixekizumab; 1143503-69-8;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL17RA Related Gene Family
- IL17RA Related Research Area
IL17RA involved in several pathways and played different roles in them. We selected most pathways IL17RA participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | FLT4;TNFRSF11B;TNFSF4;CCL27;CD40LG;CCL8;IFNA2;BMPR2A;PDGFAB |
IL17RA has several biochemical functions, for example, interleukin-17 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RA itself. We selected most functions IL17RA had, and list some proteins which have the same functions with IL17RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-17 receptor activity | IL17RE;IL17RD;IL17RB;IL17RC;IL17RA |
| protein binding | BMP4;SPPL3;SOX9;KIAA1217;SNX20;CCDC110;PNMA5;NDFIP2;RAB2B |
IL17RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RA.
IL17RE
- Q&As
- Reviews
Q&As (10)
Ask a questionSurface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.
Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.
Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.
Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.
Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.
Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.
Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.
Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.
ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.
Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.
Customer Reviews (3)
Write a reviewEffective in T-cell activation. -
Suitable for co-immunoprecipitation. -
High solubility. -
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