Recombinant Active Mouse IL1RN Protein, His-tagged(C-ter)

Cat.No. : Il1rn-168M
Product Overview : Recombinant Active Mouse IL1RN Protein with His tag (C-ter) was expressed in E. coli.
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Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Source : E. coli
Species : Mouse
Tag : His(C-ter)
Form : Powder
Bio-activity : Determined by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 cells. The ED50 for this effect is < 50 ng/mL.
AA Sequence : MRPSGKRPCKMQAFRIWDTNQKTFY LRNNQLIAGYLQGPNIKLEEKIDMV PIDLHSVFLGIHGGKLCLSCAKSGD DIKLQLEEVNITDLSKNKEEDKRFT FIRSEKGPTTSFESAACPGWFLCTT LEADRPVSLTNTPEEPLIVTKFYFQ EDQ
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 7.4)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
Gene Name : Il1rn interleukin 1 receptor antagonist [ Mus musculus ]
Official Symbol : Il1rn
Synonyms : IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor; IL-1ra; F630041P17Rik;
Gene ID : 16181
mRNA Refseq : NM_001039701
Protein Refseq : NP_001034790

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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