"IL1RN" Related Products

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Recombinant Human IL1RN protein, His-tagged

Cat.No. : IL1RN-495H
Product overview : Recombinant Human IL1RN (P18510) aa. (Arg26~Glu177) fused with His tag was produced in HEK293F cells.
Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Source : HEK293F
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 18.7kDa; Accurate Molecular Mass: 22&25kDa as determined by SDS-PAGE reducing conditions.
Protein length : Arg26~Glu177
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Characteristic : Isoelectric point is 5.4.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200ug/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
SDS-PAGE :

Gene Name : IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]
Official Symbol : IL1RN
Synonyms : IL1RN; interleukin 1 receptor antagonist; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; interleukin-1 receptor antagonist protein; IL1 inhibitor; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist
Gene ID : 3557
mRNA Refseq : NM_000577.4
Protein Refseq : NP_000568.1
UniProt ID : P18510

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