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Recombinant Bovine Fibroblast Growth Factor 2 (basic)

Cat.No. : FGF2-1182B
Product Overview : Recombinant bovine FGF2is a single, non-glycosylated polypeptide chain containing 172 amino acids.
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Cat. No. : FGF2-1182B
Description : FGF2 is asingle-chain polypeptide growth factor that plays a significant role in theprocess of wound healing and is a potent inducer of angiogenesis. Severaldifferent forms of the human protein exist ranging from 18-24 kDa in size dueto the use of alternative start sites within the FGF-2 gene. It has a 55percent amino acid residue identity to FGF-1 and has potent heparin-bindingactivity.
Source : E. coli
Species : Bovine
Form : Lyophilized from asterile filtered solution in PBS, pH 7.4+4% mannitol.
Molecular Weight : 18.5 kDa
Purity : > 97% by SDS-PAGEand HPLC analyses
Endotoxin Level : < 0.1 ng/µg ofFGF2
Biological Activity : Calculated by thedose dependant proliferation of BALB/c 3T3 cells, the ED50 is <1.0 ng/ml.
Specific Activity : 1 x 106Units/mg
Reconstitution : Centrifuge vialprior to opening. Add steriledistilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL.Further dilutions should be made in appropriate buffered solutions.
Storage : Stable at 2-8°C, butbest kept desiccated -20°C. Upon reconstitution, stable for up to 1 week at2-8°C. For longer term, store in working aliquots below -20°C. Avoid repeatedfreeze/thaw cycles.
OfficialSymbol : FGF2
Gene Name : FGF2 fibroblast growth factor2 (basic) [ Bos taurus ]
Synonyms : FGF2; fibroblastgrowth factor 2 (basic); heparin-binding growth factor 2; BFGF; HBGF-2; basicfibroblast growth factor
Gene ID : 281161
mRNA Refseq : NM_174056
Protein Refseq : NP_776481
UniProt ID : P03969
Chromosome Location : 17
Pathway : Downstream signalingof activated FGFR; FGFR ligand binding and activation; FGFR1 ligand bindingand activation; FGFR1b ligand binding and activation; FGFR1c ligand bindingand activation; FGFR2 ligand binding and activation; FGFR2c ligand bindingand activation; FGFR3 ligand binding and activation; FGFR4 ligand binding andactivation; FRS2-mediated cascade; IRS-mediated signalling; Insulin receptorsignalling cascade; MAPK signaling pathway; Melanoma
Function : growth factoractivity; heparin binding; voltage-gated calcium channel activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.


      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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