Recombinant Cynomolgus PCSK9 protein, His-tagged PCSK9-358C

Recombinant Cynomolgus PCSK9 protein, His-tagged

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Recombinant Cynomolgus PCSK9 protein, His-tagged

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Cat.No. : PCSK9-358C
Product Overview : Recombinant Cynomolgus PCSK9 protein (Gln31-Gln692), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
Description : Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Source : HEK293
Species : Cynomolgus
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 73.2 kDa. The protein migrates as 17 kDa and 65 kDa under reducing (R) condition (SDS-PAGE).
Protein length : 662
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of PCSK9-358C :

Cynomolgus PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of PCSK9-358C :

Immobilized Human LDL R, Strep Tag at 2 μg/mL (100 μL/well) can bind Cynomolgus PCSK9, His Tag with a linear range of 4-31 ng/mL (QC tested).

Gene Name : PCSK9
Official Symbol : PCSK9
Synonyms : FH3; HCHOLA3; LDLCQ1; NARC1; PC9
Gene ID : 102142788
mRNA Refseq : XM_005543257.2
Protein Refseq : XP_005543314.1
UniProt ID : G7NVZ1
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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