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Active Recombinant Mouse Il4i1 protein, His-tagged

Cat.No. : Il4i1-639M
Product Overview : Recombinant Mouse Il4i1(Leu21-Ser630) fused with His tag at C-terminal was expressed in CHO.
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Description : Interleukin four-induced gene 1 (IL-4I1) was first identified in mouse B cells as part of the response to IL-4, a key regulator of the immune response. Later, the enzyme was shown to be a member of the flavin-containing amino acid oxidase family and closely related to L-amino acid oxidases. Enzymological characterization reveals that IL-4I1 has L-amino acid oxidase activity with preference toward aromatic amino acids. Its limited expression in immune tissues, dendritic cells, and macrophages indicates that it may play an important function in the immune system.
Source : CHO
Species : Mouse
Tag : His
Predicted N Terminal : Leu21
Form : Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.
Bio-activity : Measured by its ability to produce hydrogen peroxide during the oxidation of phenylalanine. The specific activity is >100 pmol/min/μg.
Molecular Mass : Predicted Molecular Mass: 69 kDa;
SDS-PAGE: 86 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Avoid repeated freeze-thaw cycles.
6 months from date of receipt, -70 centigrade as supplied.
3 months, -70 centigrade under sterile conditions after opening.
Gene Name : Il4i1 interleukin 4 induced 1 [ Mus musculus ]
Official Symbol : Il4i1
Synonyms : IL4I1; interleukin 4 induced 1; L-amino-acid oxidase; protein Fig-1; L-amino acid oxidase; IL4-induced protein 1; interleukin-4-induced protein 1; interleukin-four induced gene 1; interleukin-four induced protein-1; interleukin-four induced gene-1 protein; LAO; Fig1; LAAO; Fig1-ps;
Gene ID : 14204
mRNA Refseq : NM_010215
Protein Refseq : NP_034345
UniProt ID : O09046
Chromosome Location : 7 B3; 7 28.93 cM
Pathway : Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Phenylalanine metabolism, organism-specific biosystem; Phenylalanine metabolism, conserved biosystem;
Function : L-amino-acid oxidase activity; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to determine the dose of IL4I1 in clinical treatment? 12/12/2022

The dose of IL4I1 in clinical treatment requires a number of preliminary studies, and is determined according to the type and severity of the patient's disease.

What are the biological functions of IL4I1? 02/04/2022

This is mainly involved in the regulation of immune response and anti-tumor effect, and has biological functions such as inhibiting T cell activation and proliferation, inducing macrophage M2 polarization, regulating T cell differentiation and apoptosis.

What problems should be paid attention to when IL4I1 is used in preclinical animal test studies? 01/09/2022

IL4I1 used in preclinical animal experimental studies needs to pay attention to its dose, administration route, administration time and other issues.

Is there any side effect of IL4I1? 01/29/2021

The application of IL4I1 may cause some side effects, such as fever, headache, fatigue, nausea, etc., but its toxic side effects are relatively small.

What is the mechanism of IL4I1 in tumor therapy? 12/30/2020

IL4I1 can inhibit the growth and spread of tumor cells, and at the same time activate immune cells in the body to enhance the body's immune monitoring ability to tumor, so as to achieve the effect of tumor treatment.

How the purification technologies of IL4I1? 06/04/2019

The purification technology of IL4I1 mainly includes affinity chromatography, ion exchange chromatography, gel filtration chromatography and so on.

Customer Reviews (3)

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Reviews
07/19/2022

    The consistency and reliability of this protein are good.

    02/13/2021

      Under the influence of temperature, humidity and light, this protein is stable and durable.

      10/24/2020

        This protein is immunogenic and allergenic, which is even more important for proteins used in drug development.

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