Recombinant Human ACHE Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | ACHE-1175H |
| Product Overview : | ACHE MS Standard C13 and N15-labeled recombinant protein (NP_056646) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 67.38 kDa |
| AA Sequence : | MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATASEAPS TCPGFTHGEA APRPGLPLPL LLLHQLLLLF LSHLRRLTRT RPLEQKLISE EDLAANDILD YKDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | ACHE acetylcholinesterase [ Homo sapiens (human) ] |
| Official Symbol : | ACHE |
| Synonyms : | ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group), acetylcholinesterase (Yt blood group), YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE; |
| Gene ID : | 43 |
| mRNA Refseq : | NM_015831 |
| Protein Refseq : | NP_056646 |
| MIM : | 100740 |
| UniProt ID : | P22303 |
◆ Recombinant Protein
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| Ache-774M | Recombinant Mouse Ache, His tagged | +Inquiry |
| Ache-07M | Recombinant Mouse Ache, His-tagged | +Inquiry |
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◆ Native Protein
| ACHE-8345H | Native Human ACHE | +Inquiry |
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◆ Lysates
| ACHE-2163MCL | Recombinant Mouse ACHE cell lysate | +Inquiry |
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◆ Assay kits
| Kit-0033 | Acetylcholinesterase Green Fluorescence Assay Kit | +Inquiry |
| Kit-0032 | Acetylcholinesterase Assay Kit | +Inquiry |
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