Recombinant Human ACHE Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ACHE-1175H |
Product Overview : | ACHE MS Standard C13 and N15-labeled recombinant protein (NP_056646) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 67.38 kDa |
AA Sequence : | MRPPQCLLHTPSLASPLLLLLLWLL GGGVGAEGREDAELLVTVRGGRLRG IRLKTPGGPVSAFLGIPFAEPPMGP RRFLPPEPKQPWSGVVDATTFQSVC YQYVDTLYPGFEGTEMWNPNRELSE DCLYLNVWTPYPRPTSPTPVLVWIY GGGFYSGASSLDVYDGRFLVQAERT VLVSMNYRVGAFGFLALPGSREAPG NVGLLDQRLALQWVQENVAAFGGDP TSVTLFGESAGAASVGMHLLSPPSR GLFHRAVLQSGAPNGPWATVGMGEA RRRATQLAHLVGCPPGGTGGNDTEL VACLRTRPAQVLVNHEWHVLPQESV FRFSFVPVVDGDFLSDTPEALINAG DFHGLQVLVGVVKDEGSYFLVYGAP GFSKDNESLISRAEFLAGVRVGVPQ VSDLAAEAVVLHYTDWLHPEDPARL REALSDVVGDHNVVCPVAQLAGRLA AQGARVYAYVFEHRASTLSWPLWMG VPHGYEIEFIFGIPLDPSRNYTAEE KIFAQRLMRYWANFARTGDPNEPRD PKAPQWPPYTAGAQQYVSLDLRPLE VRRGLRAQACAFWNRFLPKLLSATA SEAPSTCPGFTHGEAAPRPGLPLPL LLLHQLLLLFLSHLRRLTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ACHE acetylcholinesterase [ Homo sapiens (human) ] |
Official Symbol : | ACHE |
Synonyms : | ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group), acetylcholinesterase (Yt blood group), YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE; |
Gene ID : | 43 |
mRNA Refseq : | NM_015831 |
Protein Refseq : | NP_056646 |
MIM : | 100740 |
UniProt ID : | P22303 |
Products Types
◆ Recombinant Protein | ||
ACHE-36R | Recombinant Rhesus Macaque ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-2415H | Recombinant Human ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
Ache-511M | Recombinant Mouse Ache Protein, MYC/DDK-tagged | +Inquiry |
ACHE-106R | Recombinant Rat ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-04H | Active Recombinant Human ACHE Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
ACHE-8345H | Native Human ACHE | +Inquiry |
◆ Lysates | ||
ACHE-2163MCL | Recombinant Mouse ACHE cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0031 | Acetylcholinesterase Activity Colorimetric Assay Kit | +Inquiry |
Kit-0033 | Acetylcholinesterase Green Fluorescence Assay Kit | +Inquiry |
Kit-0032 | Acetylcholinesterase Assay Kit | +Inquiry |
Kit-0034 | Acetylcholinesterase Red Fluorescence Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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