| Description : |
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
149.9 kDa |
| AA Sequence : |
MHQRHPRARCPPLCVAGILACGFLL GCWGPSHFQQSCLQALEPQAVSSYL SPGAPLKGRPPSPGFQRQRQRQRRA AGGILHLELLVAVGPDVFQAHQEDT ERYVLTNLNIGAELLRDPSLGAQFR VHLVKMVILTEPEGAPNITANLTSS LLSVCGWSQTINPEDDTDPGHADLV LYITRFDLELPDGNRQVRGVTQLGG ACSPTWSCLITEDTGFDLGVTIAHE IGHSFGLEHDGAPGSGCGPSGHVMA SDGAAPRAGLAWSPCSRRQLLSLLS AGRARCVWDPPRPQPGSAGHPPDAQ PGLYYSANEQCRVAFGPKAVACTFA REHLDMCQALSCHTDPLDQSSCSRL LVPLLDGTECGVEKWCSKGRCRSLV ELTPIAAVHGRWSSWGPRSPCSRSC GGGVVTRRRQCNNPRPAFGGRACVG ADLQAEMCNTQACEKTQLEFMSQQC ARTDGQPLRSSPGGASFYHWGAAVP HSQGDALCRHMCRAIGESFIMKRGD SFLDGTRCMPSGPREDGTLSLCVSG SCRTFGCDGRMDSQQVWDRCQVCGG DNSTCSPRKGSFTAGRAREYVTFLT VTPNLTSVYIANHRPLFTHLAVRIG GRYVVAGKMSISPNTTYPSLLEDGR VEYRVALTEDRLPRLEEIRIWGPLQ EDADIQVYRRYGEEYGNLTRPDITF TYFQPKPRQAWVWAAVRGPCSVSCG AGLRWVNYSCLDQARKELVETVQCQ GSQQPPAWPEACVLEPCPPYWAVGD FGPCSASCGGGLRERPVRCVEAQGS LLKTLPPARCRAGAQQPAVALETCN PQPCPARWEVSEPSSCTSAGGAGLA LENETCVPGADGLEAPVTEGPGSVD EKLPAPEPCVGMSCPPGWGHLDATS AGEKAPSPWGSIRTGAQAAHVWTPA AGSCSVSCGRGLMELRFLCMDSALR VPVQEELCGLASKPGSRREVCQAVP CPARWQYKLAACSVSCGRGVVRRIL YCARAHGEDDGEEILLDTQCQGLPR PEPQEACSLEPCPPRWKVMSLGPCS ASCGLGTARRSVACVQLDQGQDVEV DEAACAALVRPEASVPCLIADCTYR WHVGTWMECSVSCGDGIQRRRDTCL GPQAQAPVPADFCQHLPKPVTVRGC WAGPCVGQGTPSLVPHEEAAAPGRT TATPAGASLEWSQARGLLFSPAPQP RRLLPGPQENSVQSSACGRQHLEPT GTIDMRGPGQADCAVAIGRPLGEVV TLRVLESSLNCSAGDMLLLWGRLTW RKMCRKLLDMTFSSKTNTLVVRQRC GRPGGGVLLRYGSQLAPETFYRECD MQLFGPWGEIVSPSLSPATSNAGGC RLFINVAPHARIAIHALATNMGAGT EGANASYILIRDTHSLRTTAFHGQQ VLYWESESSQAEMEFSEGFLKAQAS LRGQYWTLQSWVPEMQDPQSWKGKE GTTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
