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Recombinant Human APOC1 Protein, His-tagged

Cat.No. : APOC1-302H
Product Overview : Recombinant Human APOC1(Ser31~Ser83) fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 7.7kDa
Identity : Reconstitute in PBS or others
Protein length : Ser31~Ser83
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : APOC1 apolipoprotein C-I [ Homo sapiens ]
Official Symbol : APOC1
Synonyms : APOC1; apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1;
Gene ID : 341
mRNA Refseq : NM_001645
Protein Refseq : NP_001636
MIM : 107710
UniProt ID : P02654

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (28)

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Is APOC1 ever used in gene therapy approaches? 12/20/2022

APOC1 is currently not a primary target for gene therapy approaches. However, gene therapy techniques that aim to modulate lipid metabolism or treat specific disorders may indirectly affect APOC1 expression and function.

How is APOC1 involved in the formation of amyloid plaques in Alzheimer's disease? 09/09/2022

APOC1 has been found to interact with Amyloid-beta (Aβ), a protein that is a major component of amyloid plaques in Alzheimer's disease. APOC1 can bind to Aβ and promote its aggregation, leading to the formation of amyloid plaques in the brain. This interaction between APOC1 and Aβ is believed to contribute to the pathogenesis of Alzheimer's disease.

How does the APOC1 protein impact lipoprotein metabolism? 04/28/2022

The APOC1 protein inhibits lipoprotein lipase (LPL), an enzyme responsible for breaking down triglycerides in circulating lipoproteins. By inhibiting LPL activity, APOC1 reduces the hydrolysis of triglycerides and prolongs the presence of triglyceride-rich lipoproteins in the bloodstream, contributing to elevated plasma lipid levels.

Can APOC1 be used as a biomarker for certain diseases? 09/14/2021

There is ongoing research into the use of APOC1 as a biomarker for certain diseases. Some studies have suggested that elevated levels of APOC1 are associated with increased risk of cardiovascular disease and metabolic disorders such as obesity and insulin resistance. However, further research is needed to establish APOC1 as a definitive biomarker for these conditions.

Can APOC1 be used as a biomarker for cardiovascular disease risk? 07/31/2021

APOC1 levels have been investigated as potential biomarkers for cardiovascular disease risk. However, its utility as a standalone biomarker is limited, and it is usually considered in combination with other lipid markers, such as cholesterol and triglyceride levels.

Can APOC1 deficiency result in any health problems? 03/26/2021

There is limited information on the consequences of APOC1 deficiency in humans. In mice, complete deficiency of APOC1 has been shown to result in altered lipid metabolism, reduced plasma triglyceride levels, and increased postprandial lipid clearance. However, more research is needed to fully understand the implications of APOC1 deficiency in humans and its potential health problems.

Can APOC1 levels be modified through lifestyle changes or medications? 11/09/2020

APOC1 levels can be influenced by various factors, including lifestyle changes and medications. For example, certain medications used to treat lipid disorders, such as statins, can affect APOC1 levels. Lifestyle modifications, such as diet and exercise, can also impact APOC1 expression and lipid metabolism. However, the specific effects of lifestyle changes and medications on APOC1 levels may vary and further research is needed to fully understand these relationships.

Do lifestyle changes, such as diet and exercise, have any impact on APOC1 levels or function? 10/23/2020

Lifestyle changes, such as diet and exercise, can have an impact on APOC1 levels and function, particularly in the context of lipid metabolism. For example, a healthy diet and regular exercise can help regulate lipid levels and metabolism, which could indirectly affect APOC1 function. Some studies have suggested that dietary strategies, such as increasing the intake of omega-3 fatty acids, can influence APOC1 expression. However, the specific effects of lifestyle changes on APOC1 levels and function may vary and more research is needed to fully understand these relationships.

Are there any drugs or medications that target APOC1 or modulate its function? 08/09/2020

Currently, there are no drugs or medications specifically targeting APOC1. However, certain medications used to treat lipid disorders, such as statins, can indirectly affect APOC1 levels and function. Statins are known to reduce cholesterol levels and can influence lipid metabolism, which may indirectly impact APOC1. Additionally, other medications targeting lipid metabolism, such as fibrates, may also have an impact on APOC1. However, the specific effects of these medications on APOC1 and their therapeutic implications need further research and validation.

What are the potential implications of APOC1 in other diseases or conditions? 08/04/2020

Apart from its involvement in Alzheimer's disease and lipid metabolism, APOC1 has been implicated in other diseases and conditions. Studies have suggested its association with atherosclerosis, obesity, insulin resistance, and even certain cancers. However, the exact role of APOC1 in these conditions and its implications are still being studied. Further research is needed to fully understand the potential implications of APOC1 in other diseases and conditions.

How does APOC1 interact with other proteins in the context of disease? 06/27/2020

APOC1 can interact with various proteins in the context of disease. In Alzheimer's disease, APOC1 has been shown to interact with Amyloid-beta (Aβ), promoting its aggregation and the formation of amyloid plaques. In lipid metabolism, APOC1 interacts with apolipoprotein E (APOE) and lipoprotein lipase (LPL) to regulate the metabolism of triglyceride-rich lipoproteins. These interactions play a role in the development of lipid disorders and cardiovascular diseases. The specific mechanisms of these interactions are still being studied to better understand their implications in disease.

Are there any genetic variants of the APOC1 gene that are linked to disease susceptibility? 04/09/2020

Yes, certain genetic variants of the APOC1 gene have been associated with disease susceptibility. For example, a specific variant called APOC1-75G>A has been linked to an increased risk of Alzheimer's disease and cerebral amyloid angiopathy. Other variants of APOC1 have also been implicated in lipid disorders and cardiovascular diseases.

Can APOC1 be detected and measured in clinical laboratory tests? 02/04/2020

Yes, APOC1 levels can be measured in clinical laboratory tests. However, it is not commonly included in routine lipid panels. More specialized tests, such as apolipoprotein profiling, may be required to assess APOC1 levels specifically.

Are there any therapeutic strategies targeting APOC1 for Alzheimer's disease? 10/30/2019

Currently, there are no specific therapeutic strategies targeting APOC1 for Alzheimer's disease. However, research is underway to explore potential interventions that could modulate the interaction between APOC1 and Aβ, with the aim of inhibiting plaque formation and progression of the disease.

Does APOC1 play a role in cholesterol metabolism? 01/22/2019

Yes, APOC1 plays a role in cholesterol metabolism. It is involved in the transport of cholesterol and other lipids by interacting with lipoprotein particles. APOC1 can inhibit the activity of lipoprotein lipase, an enzyme involved in the breakdown of triglycerides, which affects the metabolism of cholesterol and other lipoproteins.

Can APOC1 levels be influenced by lifestyle factors? 01/20/2019

Yes, lifestyle factors can influence APOC1 levels. For instance, certain dietary factors, such as high-fat diets or excessive alcohol consumption, may lead to increased APOC1 production. On the other hand, regular exercise and a well-balanced diet can help maintain healthy APOC1 levels.

Are there any known genetic variations or polymorphisms in the APOC1 gene? 11/21/2018

Yes, several genetic variations and polymorphisms have been identified in the APOC1 gene. Some of these variations are associated with altered levels of circulating lipids, increased risk of cardiovascular disease, and other metabolic disorders.

Does APOC1 have any other known functions besides lipid metabolism? 11/16/2018

While the primary role of APOC1 is related to lipid metabolism, it may also have additional functions. For instance, it has been suggested to play a role in immune responses and inflammation, although further research is needed to fully elucidate these functions.

Is there any ongoing research on the APOC1 protein? 10/01/2018

Yes, researchers continue to investigate the role of APOC1 in lipid metabolism, cardiovascular disease, and other related conditions. Ongoing studies aim to understand the molecular mechanisms underlying APOC1 function, its interactions with other proteins and lipids, and explore its potential as a therapeutic target.

What are the potential therapeutic targets related to APOC1 for Alzheimer's disease or other conditions? 04/11/2018

The interaction between APOC1 and Amyloid-beta (Aβ) in Alzheimer's disease has led to the exploration of potential therapeutic targets. Some strategies being investigated include inhibiting the aggregation of Aβ, targeting APOC1 to prevent its interaction with Aβ, and modulating lipid metabolism to indirectly affect APOC1 function. Additionally, since APOC1 is involved in lipid metabolism, targeting it may have implications for lipid disorders and cardiovascular diseases. However, more research is needed to validate these targets and develop effective therapeutic interventions.

Can APOC1 levels be influenced by hormonal changes? 01/27/2018

Yes, hormonal changes can influence APOC1 levels. For instance, estrogen has been shown to increase APOC1 expression, potentially contributing to the differences observed between males and females in lipid metabolism. Hormonal changes during pregnancy and menopause can also affect APOC1 levels.

Is APOC1 associated with any other diseases or conditions? 12/11/2017

Besides its involvement in lipid metabolism and cardiovascular disease, APOC1 has also been implicated in other conditions. For example, certain APOC1 genetic variations are associated with an increased risk of Alzheimer's disease and have been linked to changes in amyloid β metabolism.

How is the APOC1 protein transported in the bloodstream? 08/02/2017

The APOC1 protein is primarily transported in the bloodstream by associating with lipoprotein particles, particularly high-density lipoproteins (HDL). It binds to the surface of these lipoproteins and is carried throughout the bloodstream, interacting with various tissues.

Are there any known therapeutic targets involving APOC1? 03/22/2017

APOC1 has been investigated as a potential therapeutic target for cardiovascular disease. Approaches focusing on reducing APOC1 levels or activity may help to lower circulating lipid levels and decrease the risk of cardiovascular events. However, more research is necessary to develop targeted therapies.

Are there any drugs or interventions targeting APOC1 for therapeutic purposes? 12/07/2016

While there are currently no specific drugs targeting APOC1, there are pharmaceutical interventions that indirectly affect APOC1 levels. For instance, statins, a class of cholesterol-lowering drugs, can reduce APOC1 synthesis and decrease circulating levels. Additionally, lifestyle modifications such as dietary changes and regular exercise can also help regulate APOC1 and improve lipid profiles.

Are there any genetic variations or mutations in the APOC1 gene associated with disease risk? 10/18/2016

Yes, there are certain genetic variations and mutations in the APOC1 gene that have been linked to disease risk. One particular variant, known as the APOC1 ε4 allele, has been found to be associated with an increased risk of Alzheimer's disease. This variant is thought to contribute to the buildup of amyloid plaques in the brain. Other genetic variations in the APOC1 gene have also been studied in relation to lipid disorders and cardiovascular diseases, but more research is needed to fully understand their impact on disease risk.

Are there any known diseases or disorders caused by mutations in the APOC1 gene? 06/10/2016

Mutations in the APOC1 gene are relatively rare, but some have been associated with certain disorders. For example, a mutation known as APOC1 Pittsburgh causes a hereditary form of cerebral amyloid angiopathy, which leads to the formation of amyloid plaques in cerebral blood vessels.

Can APOC1 levels in the blood be used as a diagnostic tool for Alzheimer's disease? 04/16/2016

Currently, APOC1 levels in the blood are not used as a diagnostic tool for Alzheimer's disease. However, some studies have suggested that altered levels of APOC1 in the blood may be associated with the disease. Further research is needed to determine the potential utility of APOC1 as a diagnostic biomarker for Alzheimer's disease.

Customer Reviews (4)

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Reviews
11/22/2022

    By considering these advantages and the supportive role of manufacturers, researchers studying APOC1 protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.

    03/29/2020

      This flexibility allows researchers to focus on specific aspects of APOC1 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

      10/08/2016

        This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.

        07/15/2016

          Such manufacturer support fosters a conducive environment for successful and impactful research outcomes.

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