Description : |
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
157.1 kDa |
AA Sequence : |
MPEQERQITAREGASRKILSKLSLP TRAWEPAMKKSFAFDNVGYEGGLDG LGPSSQVATSTVRILGMTCQSCVKS IEDRISNLKGIISMKVSLEQGSATV KYVPSVVCLQQVCHQIGDMGFEASI AEGKAASWPSRSLPAQEAVVKLRVE GMTCQSCVSSIEGKVRKLQGVVRVK VSLSNQEAVITYQPYLIQPEDLRDH VNDMGFEAAIKSKVAPLSLGPIDIE RLQSTNPKRPLSSANQNFNNSETLG HQGSHVVTLQLRIDGMHCKSCVLNI EENIGQLLGVQSIQVSLENKTAQVK YDPSCTSPVALQRAIEALPPGNFKV SLPDGAEGSGTDHRSSSSHSPGSPP RNQVQGTCSTTLIAIAGMTCASCVH SIEGMISQLEGVQQISVSLAEGTAT VLYNPAVISPEELRAAIEDMGFEAS VVSESCSTNPLGNHSAGNSMVQTTD GTPTSLQEVAPHTGRLPANHAPDIL AKSPQSTRAVAPQKCFLQIKGMTCA SCVSNIERNLQKEAGVLSVLVALMA GKAEIKYDPEVIQPLEIAQFIQDLG FEAAVMEDYAGSDGNIELTITGMTC ASCVHNIESKLTRTNGITYASVALA TSKALVKFDPEIIGPRDIIKIIEEI GFHASLAQRNPNAHHLDHKMEIKQW KKSFLCSLVFGIPVMALMIYMLIPS NEPHQSMVLDHNIIPGLSILNLIFF ILCTFVQLLGGWYFYVQAYKSLRHR SANMDVLIVLATSIAYVYSLVILVV AVAEKAERSPVTFFDTPPMLFVFIA LGRWLEHLAKSKTSEALAKLMSLQA TEATVVTLGEDNLIIREEQVPMELV QRGDIVRVVPGGKFPVDGKVLEGNT MADESLITGEAMPVTKKPGSTVIAG SINAHGSVLIKATHVGNDTTLAQIV KLVEEAQMSKAPIQQLADRFSGYFV PFIIIMSTLTLVVWIVIGFIDFGVV QKYFPNPNKHISQTEVIIRFAFQTS ITVLCIACPCSLGLATPTAVMVGTG VAAQNGILIKGGKPLEMAHKIKTVM FDKTGTITHGVPRVMRVLLLGDVAT LPLRKVLAVVGTAEASSEHPLGVAV TKYCKEELGTETLGYCTDFQAVPGC GIGCKVSNVEGILAHSERPLSAPAS HLNEAGSLPAEKDAAPQTFSVLIGN REWLRRNGLTISSDVSDAMTDHEMK GQTAILVAIDGVLCGMIAIADAVKQ EAALAVHTLQSMGVDVVLITGDNRK TARAIATQVGINKVFAEVLPSHKVA KVQELQNKGKKVAMVGDGVNDSPAL AQADMGVAIGTGTDVAIEAADVVLI RNDLLDVVASIHLSKRTVRRIRINL VLALIYNLVGIPIAAGVFMPIGIVL QPWMGSAAMAASSVSVVLSSLQLKC YKKPDLERYEAQAHGHMKPLTASQV SVHIGMDDRWRDSPRATPWDQVSYV SQVSLSSLTSDKPSRHSAAADDDGD KWSLLLNGRDEEQYITRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |