Recombinant Human BCL11A Protein, GST-tagged

• Cat.No.: BCL11A-142H
• Product Overview: Human BCL11A full-length ORF ( NP_612569.1, 1 a.a. - 243 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 53.3 kDa
• AA Sequence: MSRRKQGKPQHLSKREFSPEPLEAI LTDDEPDHGPLGAPEGDHDLLTCGQ CQMNFPLGDILIFIEHKRKQCNGSL CLEKAVDKPPSPSPIEMKKASNPVE VGIQVTPEDDDCLSTSSRGICPKQE HIADKLLHWRGLSSPRSAHGALIPT PGMSAEYAPQGICKDEPSSYTCTTC KQPFTSAWFLLQHAQNTHGLRIYLE SEHGSPLTPRVLHTPPFGVVPRELK MCGSFRMEAREPLSSEKI
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) [ Homo sapiens ]
• Official Symbol: BCL11A
• Synonyms: BCL11A; B-cell CLL/lymphoma 11A (zinc finger protein); ecotropic viral integration site 9 , EVI9; B-cell lymphoma/leukemia 11A; BCL11A L; BCL11A S; BCL11A XL; CTIP1; HBFQTL5; ZNF856; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; EVI9; BCL11A-L; BCL11A-S; BCL11A-XL; FLJ10173; FLJ34997; KIAA1809
• Gene ID: 53335
• mRNA Refseq: NM_018014
• Protein Refseq: NP_060484
• MIM: 606557
• UniProt ID: Q9H165