Recombinant Human Bruton Agammaglobulinemia Tyrosine Kinase, His-tagged
Cat.No. : | BTK-995H |
Product Overview : | Recombinant full-length human BTK was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | BTK-995H |
Description : | BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors. Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 78 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25 % glycerol. |
Specific Activity : | 43 nmol/min/mg |
Purity : | > 90 % |
Concentration : | 0.1 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | B Cell Receptor Signaling Pathway; B cell receptor signaling pathway; BCR signaling pathway; Class I PI3K signaling events; EPO signaling pathway; FAS (CD95) signaling pathway; Fc epsilon RI signaling pathway; Fc-epsilon receptor I signaling in mast cells; IL-5 Signaling Pathway; IL-6 Signaling Pathway; Kit Receptor Signaling Pathway; Osteoclast differentiation; Primary immunodeficiency |
Gene Name : | BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ] |
Official Symbol : | BTK |
Synonyms : | BTK; Bruton agammaglobulinemia tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1; MGC126261; MGC126262; tyrosine-protein kinase BTK; OTTHUMP00000023677; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase; Tyrosine-protein kinase BTK; Agammaglobulinaemia tyrosine kinase; EC 2.7.10.2; OTTHUMP00000023676 |
Gene ID : | 695 |
mRNA Refseq : | NM_000061 |
Protein Refseq : | NP_000052 |
MIM : | 300300 |
UniProt ID : | Q06187 |
Chromosome Location : | Xq21.33-q22 |
Function : | ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
BTK-26220TH | Active Recombinant Human BTK protein | +Inquiry |
BTK-457H | Recombinant Human BTK Protein, His (Fc)-Avi-tagged | +Inquiry |
BTK-0743H | Recombinant Human BTK Protein (M1-S659), Tag Free | +Inquiry |
BTK-0744H | Recombinant Human BTK Protein (M1-S659), GST tagged | +Inquiry |
BTK-2827H | Recombinant Human BTK Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
BTK-001HCL | Recombinant Human BTK cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1569 | BTK Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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