Recombinant Human C4BPB Protein, GST-Tagged

• Cat.No.: C4BPB-0054H
• Product Overview: Human C4BPB full-length ORF (AAH05378, 1 a.a. - 251 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 53.35 kDa
• AA Sequence: MFFWCACCLMVAWRVSASDEHCPEL PPVDNSIFVAKEVEGQILGTYVCIK GYHLVGKKTLFCNASKEWDNTTTEC RLGHCPDPVLVNGEFSSSGPVNVSD KITFMCNDHYILKGSNRSQCLEDHT WAPPFPICKSRDCDPPGNPVHGYFE GNNFTLGSTISYYCEDRYYLVGVQE QQCVDGEWSSALPVCKLIQEAPKPE CEKALLAFQESKNLCEAMENFMQQL KESGMTMEELKYSLELKKAELKAKL L
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: C4BPB complement component 4 binding protein, beta [ Homo sapiens ]
• Official Symbol: C4BPB
• Synonyms: C4BPB; complement component 4 binding protein, beta; C4BP, complement component 4 binding protein, beta; C4b-binding protein beta chain; C4b binding protein; beta chain; complement component 4 binding protein; C4BP
• Gene ID: 725
• mRNA Refseq: NM_000716
• Protein Refseq: NP_000707
• MIM: 120831
• UniProt ID: P20851