Recombinant Full Length Human C4BPB Protein, C-Flag-tagged

• Cat.No.: C4BPB-1931HFL
• Product Overview: Recombinant Full Length Human C4BPB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 26.2 kDa
• AA Sequence: MFFWCACCLMVAWRVSASDEHCPEL PPVDNSIFVAKEVEGQILGTYVCIK GYHLVGKKTLFCNASKEWDN TTTECRLGHCPDPVLVNGEFSSSGP VNVSDKITFMCNDHYILKGSNRSQC LEDHTWAPPFPICKSRDCDP PGNPVHGYFEGNNFTLGSTISYYCE DRYYLVGVQEQQCVDGEWSSALPVC KLIQEAPKPECEKALLAFQE SKNLCEAMENFMQQLKESGMTMEEL KYSLELKKAELKAKLL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Complement and coagulation cascades

Gene Information

• Gene Name: C4BPB complement component 4 binding protein beta [ Homo sapiens (human) ]
• Official Symbol: C4BPB
• Synonyms: C4BP
• Gene ID: 725
• mRNA Refseq: NM_000716.3
• Protein Refseq: NP_000707.1
• MIM: 120831
• UniProt ID: P20851