Native Human C4b-Binding Protein

• Cat.No.: C4BPB-184H

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: C4b-binding protein is a regulatory protein of the Complement Cascade that possesses decay-accelerating activity. Circulating in plasma, it aids in the control of fluid-phase and surface-associated activation of C3 and C5 and serves as a cofactor to Factor 1 in the proteolytic degradation of C4b. There are three isoforms circulating in plasma; 7 alpha chains and 1 Beta chain, 6 alpha chains and 1 Beta chain, and 7 alpha chains without a Beta chain. The 7 alpha, 1 Beta form is the most abundant. All C4BP molecules that contain a Beta chain circulate in plasma in a high-affinity, calcium-dependent complex with vitamin K-dependent, anticoagulant Protein S.
• Form: Frozen
• Molecular Mass: ~ 570,000 (whole molecule)~ 70-75,000 (alpha chains)~ 40-45,000 (beta chain)
• Purity: >= 95% by SDS-PAGE
• Usage: For research use only
• Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Stability: >1 year
• Storage: <=>
• Storage Buffer: 10 mM Tris, pH 7.4, with 100 mM NaCl+ 0.05% NaN3
• Publications:
  • ErpY-like lipoprotein of Leptospira outsmart host complement regulation by acquiring complement regulators, activating alternate pathway, and intervening membrane attack complex (2021)
  • Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential (2024)

Gene Information

• Gene Name: C4BPB complement component 4 binding protein, beta [ Homo sapiens ]
• Official Symbol: C4BPB
• Synonyms: C4BPB; complement component 4 binding protein, beta; C4BP, complement component 4 binding protein, beta; C4b-binding protein beta chain; C4b binding protein; beta chain; complement component 4 binding protein; C4BP
• Gene ID: 725
• mRNA Refseq: NM_000716
• Protein Refseq: NP_000707
• MIM: 120831
• UniProt ID: P20851
• Chromosome Location: 1q32
• Pathway: Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Pertussis, organism-specific biosystem