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Recombinant Human CA2 Protein, GST-Tagged

Cat.No. : CA2-0238H
Product Overview : Human CA2 full-length ORF (NP_000058.1, 1 a.a. - 260 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 55.6 kDa
AA Sequence : MSHHWGYGKHNGPEHWHKDFPIAKG ERQSPVDIDTHTAKYDPSLKPLSVS YDQATSLRILNNGHAFNVEFDDSQD KAVLKGGPLDGTYRLIQFHFHWGSL DGQGSEHTVDKKKYAAELHLVHWNT KYGDFGKAVQQPDGLAVLGIFLKVG SAKPGLQKVVDVLDSIKTKGKSADF TNFDPRGLLPESLDYWTYPGSLTTP PLLECVTWIVLKEPISVSSEQVLKF RKLNFNGEGEPEELMVDNWRPAQPL KNRQIKASFK
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CA2 carbonic anhydrase II [ Homo sapiens ]
Official Symbol : CA2
Synonyms : CA2; carbonic anhydrase II; carbonic anhydrase 2; CA II; CAII; Car2; CAC; carbonic anhydrase B; carbonic anhydrase C; carbonic dehydratase; carbonate dehydratase II; CA-II;
Gene ID : 760
mRNA Refseq : NM_000067
Protein Refseq : NP_000058
MIM : 611492
UniProt ID : P00918

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Is CA2 involved in any particular pathological conditions? 07/05/2022

CA2 deficiency is a rare autosomal recessive disorder with metabolic acidosis and osteopetrosis.

What are the known inhibitors of CA2 and their clinical implications? 02/23/2022

Acetazolamide is a known inhibitor, used clinically for glaucoma and altitude sickness.

How do mutations in the CA2 gene influence enzyme activity or stability? 06/13/2021

Some mutations can lead to CA2 deficiency, affecting acid-base balance and leading to metabolic acidosis.

How does CA2's enzymatic activity compare to other carbonic anhydrase isoforms? 07/28/2019

CA2 is one of the most efficient and fastest enzymes, displaying higher activity than many other isoforms.

What role does CA2 play in the physiological regulation of pH? 07/23/2019

CA2 accelerates the reversible conversion of CO2 and water to bicarbonate and protons, aiding in pH regulation.

Are there specific cellular pathways where CA2 plays a significant role? 11/14/2018

CA2 plays a crucial role in CO2 transport and acid-base balance in various tissues.

How is CA2 expression distributed across different human tissues? 07/04/2018

CA2 is ubiquitously expressed but is particularly abundant in red blood cells and certain epithelial tissues.

Customer Reviews (3)

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Reviews
05/01/2022

    Efficient sample processing, a time-saving boon for researchers.

    08/30/2021

      Professional expertise, elevates our protein research projects.

      06/08/2021

        Invaluable assistance for intricate protein experiments.

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