Recombinant Human CA9 Protein, MYC/DDK-tagged
Cat.No. : | CA9-2272H |
Product Overview : | Recombinant human CA9 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293 |
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- Gene Information
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Description : | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 45.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | CA9 carbonic anhydrase IX [ Homo sapiens ] |
Official Symbol : | CA9 |
Synonyms : | CAIX; MN |
Gene ID : | 768 |
mRNA Refseq : | NM_001216 |
Protein Refseq : | NP_001207 |
MIM : | 603179 |
UniProt ID : | Q16790 |
Products Types
◆ Recombinant Protein | ||
CA9-481H | Recombinant Human CA9 Protein, His (Fc)-Avi-tagged | +Inquiry |
Car9-1962M | Recombinant Mouse Car9 Protein, Myc/DDK-tagged | +Inquiry |
CA9-116H | Recombinant Human CA9 Protein, His-tagged | +Inquiry |
CA9-0250H | Recombinant Human CA9 Protein, GST-Tagged | +Inquiry |
CA9-117H | Recombinant Human CA9 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CA9-1447CCL | Recombinant Canine CA9 cell lysate | +Inquiry |
CA9-2189MCL | Recombinant Mouse CA9 cell lysate | +Inquiry |
CA9-3065HCL | Recombinant Human CA9 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionThe HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.
CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.
CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.
Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.
Potential modifications like glycosylation can be identified using techniques like mass spectrometry.
Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.
CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.
Customer Reviews (3)
Write a reviewExceptional consistency, vital for our research's reliability.
Critical support for our protein analysis and quantification.
Unmatched accuracy in protein identification and sequencing.
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