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Official Full Name carbonic anhydrase IX
Background Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas.
Synonyms CA9; carbonic anhydrase IX; MN; CAIX; carbonic anhydrase 9; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonic dehydratase; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; MN/CA9
    • Species :
    • Canine
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • His-Avi
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CA9-151H Recombinant Human CA9 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CA9-0250H Recombinant Human CA9 Protein, GST-Tagged Wheat Germ GST
    Human CA9-10627H Recombinant Human CA9 protein, GST-tagged E.coli GST
    Human CA9-2272H Recombinant Human CA9 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CA9-256H Recombinant Human CA9 protein, His-tagged HEK293 His
    Human CA9-27269TH Recombinant Human CA9 Wheat Germ N/A
    Human CA9-3065HCL Recombinant Human CA9 cell lysate Human Cell N/A
    Human CA9-4196H Recombinant Human CA9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CA9-7844H Recombinant Human CA9 protein, His-tagged E.coli His
    Human CA9-790H Recombinant Human CA9 protein, His-Avi-tagged HEK293 His-Avi
    Human CA9-804HG GMP Recombinant Human CA9 protein, His-tagged HEK293 His
    Human CA9-890H Recombinant Human CA9, Fc tagged Human Cell Fc
    Human CA9-890HA Recombinant Human CA9 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CA9-890HP Recombinant Human CA9 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Mouse CA9-2189MCL Recombinant Mouse CA9 cell lysate Human Cell N/A
    Mouse Car9-914M Recombinant Mouse Car9, His tagged Human Cell His
    Canine CA9-1039C Recombinant Canine CA9 Protein, His-tagged HEK293 His
    Canine CA9-1447CCL Recombinant Canine CA9 cell lysate Human Cell N/A
    Canine CA9-1544C Recombinant Canine CA9 Protein, Fc-tagged HEK293 Fc
    Canine CA9-1544CA Recombinant Canine CA9 protein, Fc-tagged, APC labeled HEK293 Fc
    Canine CA9-1544CP Recombinant Canine CA9 protein, Fc-tagged, R-PE labeled HEK293 Fc

    ca9 involved in several pathways and played different roles in them. We selected most pathways ca9 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ca9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nitrogen metabolism CAR15; CA12; CA5; Car8; CAHZ; CAR3; CA5A; CA9; CA4; GLUD1

    ca9 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ca9 itself. We selected most functions ca9 had, and list some proteins which have the same functions with ca9. You can find most of the proteins on our site.

    Function Related Protein
    carbonate dehydratase activity CA8; CA1; CA2; CA4; Car9; CAHZ; CA15B; CA12; CAR15; CAR5A
    zinc ion binding RBBP6; JADE3; RORB; ZFAND2A; ADAM15; RORCA; ZNF385A; CAR6; TRIM26; ZFP346

    ca9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ca9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ca9.

    Kato, Y; Hagiwara, M; et al. TNF-alpha augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1. BMC MICROBIOLOGY 14:-(2014).
    Fujihara, R; Usui, M; et al. Tumor necrosis factor-alpha enhances RANKL expression in gingival epithelial cells via protein kinase A signaling. JOURNAL OF PERIODONTAL RESEARCH 49:508-517(2014).

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