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CA9

  • Official Full Name

    carbonic anhydrase IX

  • Overview

    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas.
  • Synonyms

    CA9; carbonic anhydrase IX; MN; CAIX; carbonic anhydrase 9; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonic dehydratase; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; MN/CA9;

  • GMP Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Dog
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Avi
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His\Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA9-804HG Active GMP Recombinant Human CA9 protein HEK293 DNA sequence encoding Human Carbonic Anhydrase IX(NP_001207.2) was expressed with His tag at the C-terminal.
Human CA9-854H Active Recombinant Human CA9 Protein, His-tagged HEK293 His Ser 27-Ala 146
Human CA9-0250H Recombinant Human CA9 Protein, GST-Tagged Wheat Germ GST
Human CA9-10627H Recombinant Human CA9 protein, GST-tagged E.coli GST 111 - 459 aa
Human CA9-27269TH Recombinant Human CA9 Wheat Germ N/A 459 amino acids
Human CA9-890H Active Recombinant Human CA9 protein, hFc-tagged HEK293 hFc Met1-Asp414
Human CA9-7844H Recombinant Human CA9 protein, His-tagged E.coli His Pro59~Asp414
Human CA9-256H Recombinant Human CA9 protein, His-tagged HEK293 His Gln138-Asp414
Human CA9-3065HCL Recombinant Human CA9 cell lysate Human Cell N/A
Human CA9-790H Recombinant Human CA9 protein, His-Avi-tagged HEK293 His-Avi Gln 38-Asp 414
Human CA9-256HAF488 Recombinant Human CA9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Gln138-Asp414
Human CA9-151H Recombinant Human CA9 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CA9-4386H Recombinant Human CA9 protein, GST-tagged E.coli GST 64-399aa
Human CA9-4196H Recombinant Human CA9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CA9-890HAF488 Recombinant Human CA9 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 615
Human CA9-255H Recombinant Human CA9(Gln38-Asp414) Protein, C-6*His-tagged HEK293 His
Human CA9-2272H Recombinant Human CA9 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA9-4387H Recombinant Human CA9 protein, His-GST-tagged E.coli His/GST 64-399aa
Human CA9-2745HF Recombinant Full Length Human CA9 Protein, GST-tagged In Vitro Cell Free System GST 459 amino acids
Human CA9-256HAF555 Recombinant Human CA9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Gln138-Asp414
Human CA9-890HP Recombinant Human CA9 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CA9-1712HFL Recombinant Full Length Human CA9 Protein, C-Flag-tagged Mammalian cells Flag
Human CA9-192H Recombinant Human CA9 Protein, His\Avi-tagged Human Cell His\Avi
Human CA9-890HAF647 Recombinant Human CA9 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 615
Human CA9-890HA Recombinant Human CA9 protein, Fc-tagged, APC labeled HEK293 Fc
Human CA9-496H Active Recombinant Human CA9 protein, hFc-tagged HEK293 hFc Gln138-Asp414
Human CA9-481H Recombinant Human CA9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CA9-256HF Recombinant Human CA9 Protein, His-tagged, FITC conjugated HEK293 His Gln138-Asp414
Human CA9-790HB Recombinant Human CA9(Gln38-Asp414) Protein, C-Avi-6*His-tagged, Biotinylated HEK293 Avi-His
Human CA9-48HF Recombinant Full Length Human CA9 Protein In Vitro Cell Free System 459 amino acids
Human CA9-116H Recombinant Human CA9 Protein, His-tagged HEK293 His 459
Human CA9-481H-B Recombinant Human CA9 Protein Pre-coupled Magnetic Beads HEK293
Human CA9-890HAF555 Recombinant Human CA9 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 615
Human CA9-4675H Active Recombinant Human CA9 Protein, His-tagged, PE-Labeled HEK293 His Gln 38 - Asp 414
Human CA9-256HAF647 Recombinant Human CA9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Gln138-Asp414
Human CA9-890HF Recombinant Human CA9 Protein, Fc-tagged, FITC conjugated HEK293 Fc 615
Human CA9-3365H Recombinant Human CA9 protein, His-tagged HEK293 His Pro59~Asp414
Human CA9-117H Recombinant Human CA9 Protein, His-tagged HEK293 His 459
Human CA9-0355H Recombinant Human CA9 Protein (Pro59-Asp414), His-tagged E.coli His Pro59-Asp414
Human CA9-4674H Recombinant Human CA9 Protein, His-tagged, FITC-Labeled HEK293 His Gln 38 - Asp 414
Mouse Car9-7845M Recombinant Mouse Car9 protein, His-tagged E.coli His Glu88~Glu280 (Accession # Q8VHB5)
Mouse CA9-2189MCL Recombinant Mouse CA9 cell lysate Human Cell N/A
Mouse Car9-1962M Recombinant Mouse Car9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Car9-914MAF488 Recombinant Mouse Car9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 370
Mouse Car9-914MF Recombinant Mouse Car9 Protein, His-tagged, FITC conjugated HEK293 His 370
Mouse Car9-914MAF647 Recombinant Mouse Car9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 370
Mouse Car9-914MAF555 Recombinant Mouse Car9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 370
Dog CA9-1039CAF488 Active Recombinant Canine CA9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 384
Dog CA9-1039CAF555 Active Recombinant Canine CA9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 384
Dog CA9-1544CF Active Recombinant Canine CA9 Protein, Fc-tagged, FITC conjugated HEK293 Fc 614
Dog CA9-1544CAF555 Active Recombinant Canine CA9 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 614
Dog CA9-1544CAF488 Active Recombinant Canine CA9 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 614
Dog CA9-1039CAF647 Active Recombinant Canine CA9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 384
Dog CA9-1544CAF647 Active Recombinant Canine CA9 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 614
Dog CA9-1039CF Active Recombinant Canine CA9 Protein, His-tagged, FITC conjugated HEK293 His 384
Canine CA9-1039C Active Recombinant Canine CA9 Protein, His-tagged HEK293 His
Canine CA9-1447CCL Recombinant Canine CA9 cell lysate Human Cell N/A
Canine CA9-1544C Active Recombinant Canine CA9 protein, hFc-tagged HEK293 hFc Met1-Leu410
Canine CA9-1544CP Recombinant Canine CA9 protein, Fc-tagged, R-PE labeled HEK293 Fc
Canine CA9-1544CA Recombinant Canine CA9 protein, Fc-tagged, APC labeled HEK293 Fc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA9 involved in several pathways and played different roles in them. We selected most pathways CA9 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCA8;Car9;CAR6;CAR7;CA3;Car2;CAR13;CA7;CA4A

CA9 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA9 itself. We selected most functions CA9 had, and list some proteins which have the same functions with CA9. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCar12;CA4B;CA15B;CAR5A;CAR15;CA3;Car14;CA12;Car2
zinc ion bindingZNF259;TIMM9;ZFAND5B;TLL1;RNF19A;RNF128A;USP5;PTER;PAPLNB

CA9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA9.

Research Area

Related articles

Kato, Y; Hagiwara, M; et al. TNF-alpha augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1. BMC MICROBIOLOGY 14:-(2014).
Fujihara, R; Usui, M; et al. Tumor necrosis factor-alpha enhances RANKL expression in gingival epithelial cells via protein kinase A signaling. JOURNAL OF PERIODONTAL RESEARCH 49:508-517(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What signaling pathways are known to regulate CA9 expression? 06/15/2022

The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

How is CA9 expression regulated in hypoxic conditions? 04/15/2021

CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

What post-translational modifications have been identified on CA9? 11/23/2017

Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

What roles does CA9 play in tumor physiology? 07/06/2017

CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

Customer Reviews (3)

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Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

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