Recombinant Human CAMK2A Protein (A2-H478), GST tagged

• Cat.No.: CAMK2A-0178H
• Product Overview: Recombinant Human GST-TEV-GG-CaMK2α(A2-H478 end) Protein was expressed in Insect cell.

Specification

• Description: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: A2-H478
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 85%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 5% glycerol, 5mM DTT, 0.1M Trehalose
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CAMK2A calcium/calmodulin-dependent protein kinase II alpha [ Homo sapiens (human) ]
• Official Symbol: CAMK2A
• Synonyms: CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin dependent protein kinase (CaM kinase) II alpha, CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; calcium/calmodulin dependent protein kinase II alpha B subunit; calcium/calmodulin dependent protein kinase type II alpha chain; CaM kinase II alpha subunit; CaM kinase II alpha chain; CaMK II alpha subunit; CaMKIINalpha; KIAA0968; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; CAMKA
• Gene ID: 815
• mRNA Refseq: NM_015981
• Protein Refseq: NP_057065
• MIM: 114078
• UniProt ID: Q9UQM7