Recombinant Human Cathepsin D
|Product Overview :||Recombinant full length human Catheprsin D protein expressed inE.coli,48kDa.|
- Gene Information
- Related Products
|Cat. No. :||CTSD-90H|
|Description :||Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.|
|Presentation :||5µg/50µl purified human Cathepsin D protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.|
|Applications :||•ELISA •Inhibition Assays •Western Blotting|
|Characterization :||On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa.|
|Activity :||Not known.|
|Storage :||Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.|
|Gene Name :||CTSD cathepsin D [ Homo sapiens ]|
|Synonyms :||CTSD; cathepsin D; CPSD; CLN10; MGC2311; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; EC 184.108.40.206; cathepsin D (lysosomal aspartyl protease);Cathepsin D light chain; Cathepsin D heavy chain|
|Gene ID :||1509|
|mRNA Refseq :||NM_001909|
|Protein Refseq :||NP_001900|
|UniProt ID :||P07339|
|Chromosome Location :||11p15.5|
|Function :||aspartic-type endopeptidase activity; peptidase activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)Write a review
Good at western-blot experiments. -
In experiments, the biocompatibility performed well. -
The experimental conditions are broad, and the experimental results are accurate and repeatable. -
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