Recombinant Human Cathepsin D

Cat.No. : CTSD-90H
Product Overview : Recombinant full length human Catheprsin D protein expressed inE.coli,48kDa.
  • Specification
  • Gene Information
  • Related Products
  • Download
Cat. No. : CTSD-90H
Description : Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.
Source : E.coli
Presentation : 5µg/50µl purified human Cathepsin D protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Applications : •ELISA •Inhibition Assays •Western Blotting
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa.
Activity : Not known.
Storage : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name : CTSD cathepsin D [ Homo sapiens ]
Synonyms : CTSD; cathepsin D; CPSD; CLN10; MGC2311; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; EC 3.4.23.5; cathepsin D (lysosomal aspartyl protease);Cathepsin D light chain; Cathepsin D heavy chain
Gene ID : 1509
mRNA Refseq : NM_001909
Protein Refseq : NP_001900
MIM : 116840
UniProt ID : P07339
Chromosome Location : 11p15.5
Pathway : Lysosome
Function : aspartic-type endopeptidase activity; peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
07/12/2021

    Good at western-blot experiments.

    03/28/2021

      In experiments, the biocompatibility performed well.

      03/02/2021

        The experimental conditions are broad, and the experimental results are accurate and repeatable.

        Q&As (6)

        Ask a question
        What is the relationship between CTSD proteins and cognitive function? 05/02/2022

        There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.

        What is the relationship between changes in CTSD protein levels and disease? 12/13/2021

        In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.

        For people with cognitive decline, how do you assess their CTSD protein levels? 01/19/2021

        For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.

        How can treatment be used to alter the level or function of the CTSD protein? 11/14/2020

        It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.

        Is CTSD protein involved in Parkinson's disease? 02/08/2020

        People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.

        In which diseases does the CTSD protein play a role? 12/11/2019

        CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.

        Ask a Question for All CTSD Products

        Required fields are marked with *

        My Review for All CTSD Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends