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Official Full Name cathepsin D
Background This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
Synonyms CTSD; cathepsin D; CPSD; CLN10; HEL-S-130P; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P;
    • Species :
    • Chicken
    • Cricetulus Griseus
    • Cynomolgus
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • Human Cell
    • Human Liver
    • Human Plasma
    • Mammalian Cell
    • Mammalian cells
    • Rabbit
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTSD-11684H Recombinant Human CTSD, GST-tagged E.coli GST
    Human CTSD-1648H Native Human Cathepsin D Human Liver N/A
    Human CTSD-1649H Recombinant Human CTSD, His-tagged Mammalian cells His
    Human CTSD-1735HCL Recombinant Human CTSD cell lysate Human Cell N/A
    Human CTSD-189H Native Human Cathepsin D Human Plasma N/A
    Human CTSD-207H Recombinant Human CTSD, His-tagged, C13&N15 Labeled HEK293 His
    Human CTSD-2103H Recombinant Human CTSD Protein, GST-tagged Wheat Germ GST
    Human CTSD-218H Recombinant Human CTSD, His-tagged HEK293 His
    Human CTSD-26213TH Recombinant Human CTSD E.coli N/A
    Human CTSD-26411TH Native Human Cathepsin D protein Human Liver N/A
    Human CTSD-27858TH Native Human CTSD N/A
    Human CTSD-522H Recombinant Human CTSD protein, His-tagged HEK293F His
    Human CTSD-5325D Native Human CTSD protein Human liver N/A
    Human CTSD-6918H Recombinant Human CTSD, His tagged Human Cell His
    Human CTSD-854H Recombinant Human CTSD Protein, GST-His-tagged E.coli GST/His
    Human CTSD-90H Recombinant Human Cathepsin D E.coli N/A
    Mouse CAB11522RM Rabbit Anti-Mouse Cathepsin D Monoclonal Antibody Rabbit N/A
    Mouse Ctsd-2369M Recombinant Mouse Ctsd Protein, His-tagged HEK293 His
    Mouse Ctsd-280M Recombinant Mouse Ctsd, His tagged Human Cell His
    Mouse CTSD-3023MCL Recombinant Mouse CTSD cell lysate Human Cell N/A
    Mouse Ctsd-6760M Recombinant Mouse Ctsd protein, His-tagged E.coli His
    Rat Ctsd-6761R Recombinant Rat Ctsd protein, His-tagged E.coli His
    Rat Ctsd-6762R Recombinant Rat Ctsd protein, His & GST-tagged E.coli His/GST
    Cynomolgus CTSD-429C Recombinant Cynomolgus CTSD Protein, His-tagged HEK293 His
    Rhesus Macaque CTSD-1088R Recombinant Rhesus monkey CTSD Protein, His-tagged Mammalian Cell His
    Chicken CTSD-6732C Recombinant Chicken CTSD Mammalian Cell His
    Zebrafish CTSD-9232Z Recombinant Zebrafish CTSD Mammalian Cell His
    Cricetulus Griseus CTSD-435C Recombinant Cricetulus Griseus CTSD Protein (65-408 aa), His-SUMO-tagged E.coli His/SUMO
    Kit-0264 Cathepsin D Inhibitor Screening Kit N/A

    ctsd involved in several pathways and played different roles in them. We selected most pathways ctsd participated on our site, such as Adaptive Immune System, Ceramide signaling pathway, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ctsd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System MAP3K8; LILRA2; KIF15; Siglece; FBXO17; KIF22; KIF5B; CHUK; SH3RF1; RNF34
    Ceramide signaling pathway PAWR; EGF; CTSD; CRADD; DERL3
    Collagen degradation CTSB; COL13A1; COL9A3; CTSLL; MMP20; LOC100686744; COL25A1; MMP8; MGC174857; CTSD
    Degradation of the extracellular matrix CTSS; LOC100686744; COL9A3; BMP1A; COL25A1; TLL2; CTSB; ADAM15; ADAMTS18; FURINA
    Direct p53 effectors HIC1; PRDM1; DDB2; ARID3A; SMARCA4; BCL2L14; CD82; FOXA1; EPHA2; TADA2B
    Extracellular matrix organization LOC100514666; ASPN; MATN1; MFAP2; COL15A1B; PCOLCEA; NID1; DAG1; ABHD1; CAPNS1
    Immune System ASB11; TRIM48; UBA5; DUSP3B; CD226; IFIT11; ARIH2; FCGR1B; SRMS; LGALS3
    LKB1 signaling events SIK3; MARK2; MARK4; CDC37; MAP2; CTSD; STK11IP

    ctsd has several biochemical functions, for example, aspartic-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ctsd itself. We selected most functions ctsd had, and list some proteins which have the same functions with ctsd. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity BACE2; BACE1; CNTNAP5A; PGA; ATP6AP2; NOTS; NRIP2; REN2; NAPSA; NRIP3
    protein binding KCNJ5; PSMB2; RIN1; STAT2; MAP2K7; BTF3L4; GPN3; RIPK1L; ENSA; UBE4A

    ctsd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ctsd here. Most of them are supplied by our site. Hope this information will be useful for your research of ctsd.

    env; APP; hly; HBA1; MAPK1; purT; q7cjw2_yerpe; leuD; RASSF10; ere_dna; RASSF9; cona_canen; H2AFX; VCAM1; ATP6V1A; RASSF7

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