|Official Full Name||cathepsin D|
|Background||This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]|
|Synonyms||CTSD; cathepsin D; CPSD; CLN10; HEL-S-130P; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ctsd involved in several pathways and played different roles in them. We selected most pathways ctsd participated on our site, such as Adaptive Immune System, Ceramide signaling pathway, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ctsd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||Siglece; ARF1; RACGAP1; ERAP1; SLAMF6; ASB9; TPP2; MGC174857; SIGLEC10; RNF138|
|Ceramide signaling pathway||CTSD; CRADD; EGF; PAWR; DERL3|
|Collagen degradation||COL23A1; ADAM10; COL13A1; MMP15; CTSLL; MGC174152; LOC100686744; MGC174857; COL9A3; ADAM9|
|Degradation of the extracellular matrix||CMA1; MMP17; COL23A1; COL15A1B; KLK7; CTSB; TPSAB1; ADAM8A; MMP15; BSG|
|Direct p53 effectors||PCBP4; DDX5; TRIAP1; EDN2; DUSP5; CEBPZ; FOXA1; DGCR8; PPM1J; CD82|
|Extracellular matrix organization||CTS7; LOXL4; MATN3B; COL4A4; MGC174152; F11R.2; JAM2B; SERPINH1; LOX; MMP15|
|Immune System||BTLA; ADAR; KIF4A; LRRFIP1; ALCAMB; UFL1; GM11711; UBR2; CD200R3; EIF4E3|
|LKB1 signaling events||SIK3; STK11IP; MAP2; MARK2; MARK4; CTSD; CDC37|
ctsd has several biochemical functions, for example, aspartic-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ctsd itself. We selected most functions ctsd had, and list some proteins which have the same functions with ctsd. You can find most of the proteins on our site.
|aspartic-type endopeptidase activity||PGA5; SPPL3; PGC; ATP6AP2; Casp3; CTSD; DDI2; NRIP2; NOTS; NRIP3|
|protein binding||RCAN3; AACS; ABHD1; DNAAF2; CPSF7; UHRF2; ROBO1; PSMD11; CNGA1; FDXR|
ctsd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ctsd here. Most of them are supplied by our site. Hope this information will be useful for your research of ctsd.
env; APP; hly; HBA1; MAPK1; purT; q7cjw2_yerpe; leuD; RASSF10; ere_dna; RASSF9; cona_canen; H2AFX; VCAM1; ATP6V1A; RASSF7