Cat.No.:	CD70-56H
Product Overview:	Recombinant human CD70, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description:	CD70, also known as CD70 antigen, is a transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. This protein binds to the transmembrane glycoprotein CD27 ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T cell activation, and thus is proliferation of co-stimulated T cells, as well as the generation of cytolytic T cells.
Source:	Insect cells
Species:	Human
Tag:	His tag
Form:	Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass:	18.2kDa (164aa)
AA Sequence:	ADPQRFAQAQ QQLPLESLGW DVAELQLNHT GPQQDPRLYW QGGPALGRSF LHGPELDKGQ LRIHRDGIYM VHIQVTLAIC SSTTASRHHP TTLAVGICSP ASRSISLLRL SFHQGCTIAS QRLTPLARGD TLCTNLTGTL LPSRNTDETF FGVQWVRPHH HHHH
Endotoxin:	< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity:	>90% by SDS - PAGE
Storage:	Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration:	0.25mg/ml (determined by Absorbance at 280nm)

Gene Name:	CD70 CD70 molecule [ Homo sapiens ]
Official Symbol:	CD70
Synonyms:	CD70; CD70 molecule; CD70 antigen; CD27L; CD27-L; CD27LG; TNFSF7
Gene ID:	970
mRNA Refseq:	NM_001252
Protein Refseq:	NP_001243
MIM:	602840
UniProt ID:	P32970
Chromosome Location:	19p13
Pathway:	Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function:	cytokine activity; protease binding; protein binding; receptor binding; tumor necrosis factor receptor binding;

Online Inquiry