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CD70

Official Full Name

Cd70 CD70 antigen
Synonyms

CD70; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7; Cd27l; CD27LG; Tnfsf7;

Type

Recombinant Proteins
Cell & Tissue Lysates
GMP Proteins
Protein Pre-coupled Magnetic Beads

Species

Cynomolgus
Human
Mouse
Mus musculus (Mouse)
Rat
Rhesus monkey
Rhesus Monkey

Source

CHO
E.coli
E.coli expression system
HEK293
HEK293T
Human Cell
Human cells
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Mammalian cells
Wheat Germ
Yeast

Tag

C
His
Fc
Avi
Flag
GST
HA
GCN4
IZ
hIgG4
FLAG
StrepII
mFc
lFc
mIgG2a
Myc
DDK
N
hFc
Non
rFC

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CD70-116H	Active Recombinant Human CD70, His-tagged	CHO	His		Inquiry
Human	CD70-218H	Active Recombinant Human CD70 Protein, HA/GCN4-IZ-tagged	HEK293	HA/GCN4-IZ	Gln39-Pro193	Inquiry
Human	CD70-434H	Recombinant Human CD70 protein, His-Flag-tagged	HEK293	N-His-Flag	Gln45-Pro193	Inquiry
Human	CD70-196H	Recombinant Human CD70 protein, His-tagged	HEK293	N-His	Leu50-Pro193	$798 / 100µg
Human	CD70-639P	Active Recombinant Human CD70 protein, Fc-tagged, R-PE labeled	HEK293	Fc	Gln 39-Pro 193	Inquiry
Human	CD70-5764H	Recombinant Human CD70 protein, His-tagged, Biotinylated(Primary Amine Labeling)	HEK293	N-His	Leu50-Pro193	Inquiry
Human	CD70-001H	Recombinant Human CD70 molecule Protein, His tagged	HEK293	C-His	45-193 aa	Inquiry
Human	CD70-0848H	Recombinant Human CD70 Protein	Wheat Germ	Non		Inquiry
Human	CD70-6722H	Recombinant Human CD70 protein, His & GST-tagged	E.coli	His&GST	Gln47~Val191	Inquiry
Human	CD70-0851H	Recombinant Human CD70 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CD70-0849H	Recombinant Human CD70 Protein, His-Flag-StrepII-Tagged	Human Cell	His&Flag&StrepII	52-193	Inquiry
Human	CD70-639	Recombinant Human CD70 protein, hFc-tagged	HEK293	N-hFc	Gln39-Pro193	$461 / 50µg
Human	CD70-56H	Recombinant Human CD70 protein, His-tagged	Insect Cell	His		Inquiry
Human	CD70-891H	Recombinant Human CD70 Protein, Fc-tagged	HEK293	Fc	Gln39-Pro193	Inquiry
Human	CD70-2710HCL	Recombinant Human CD70 cell lysate	Human Cell	Non		Inquiry
Human	CD70-892H	Active Recombinant Human CD70 protein, hFc&Avi-tagged, Biotinylated	HEK293	Fc&Avi	Gln39-Pro193	$786 / 20µg
Human	CD70-437H	Recombinant Human CD70 Protein (Gln39-Pro193), RIgG Fc-tagged	HEK293	rFC	Gln39-Pro193	$461 / 50µg
Human	CD70-891HA	Recombinant Human CD70 protein, Fc-tagged, APC labeled	HEK293	Fc		$1,598 / 50μg $2,498 / 100μg
Human	CD70-073H	Active Recombinant Human CD70, hFc-tagged	HEK293	Fc	Ser52-Pro193	Inquiry
Human	CD70-639A	Recombinant Human CD70 protein, Fc-tagged, APC labeled	HEK293	Fc		Inquiry
Human	CD70-328H	Active Recombinant Human CD70 protein, lFc-tagged	HEK293	lFc	Ser 52 - Pro 193	$798 / 100µg
Human	CD70-436H	Recombinant Human CD70 Protein (Gln39-Pro193), MIgG1 Fc-tagged	HEK293	mFc	Gln39-Pro193	Inquiry
Human	CD70-545H	Recombinant Human CD70 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	CD70-089H	Recombinant Human CD70 protein, His-Flag-tagged	HEK293	His&Flag	It contains Gln50-Pro193 Trimer.	$798 / 100µg
Human	CD70-3030HF	Recombinant Full Length Human CD70 Protein	In Vitro Cell Free System		392 amino acids	Inquiry
Human	CD70-328HG	Active GMP Recombinant Human CD70 protein	HEK293		DNA sequence encoding Human CD27 Ligand(UniProtKB/Swiss-Prot: P32970.2) was expressed with His tag at the C-terminal.	Inquiry
Human	CD70-623H	Recombinant Human CD70 Protein, Fc-tagged	HEK293	Fc	193	Inquiry
Human	CD70-151H	Recombinant Human CD70 Protein, DYKDDDDK-tagged	Human cells	Flag		Inquiry
Human	CD70-206H	Recombinant Human CD70 Protein, C-His-tagged	E.coli	His		Inquiry
Human	CD70-2517H	Recombinant Human CD70 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	CD70-2985H	Active Recombinant Human CD70 protein, His-Flag-tagged, FITC-Labeled	HEK293	His&Flag	Ser 52-Pro 193	Inquiry
Human	CD70-891HAF555	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	Gln39-Pro193	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-5366H	Recombinant Human CD70 Protein (Gln39-Pro193), N-His tagged	Mammalian cells	His	Gln39-Pro193	Inquiry
Human	CD70-639F	Recombinant Human CD70 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	413	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-038H	Recombinant Human CD70 Protein, Leu50-Pro193, N-His tagged, Biotinylated	HEK293	His	Leu50-Pro193	Inquiry
Human	CD70-891HAF647	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	Gln39-Pro193	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-3100H	Recombinant Human CD70 Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	CD70-072H	Active Recombinant Human CD70 Protein, His-Flag-tagged	HEK293	His&Flag	Ser52-Pro193	Inquiry
Human	CD70-891HP	Recombinant Human CD70 protein, Fc-tagged, R-PE labeled	HEK293	Fc		Inquiry
Human	CD70-891HF	Recombinant Human CD70 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	Gln39-Pro193	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-435H	Recombinant Human CD70(Gln45-Pro193) Protein, C-mFc-tagged	HEK293	mFc	Gln45-Pro193	Inquiry
Human	CD70-545H-B	Recombinant Human CD70 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	CD70-639AF488	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	413	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-3055HF	Recombinant Full Length Human CD70 Protein, GST-tagged	In Vitro Cell Free System	GST	193 amino acids	Inquiry
Human	CD70-639AF647	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	413	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-2986H	Active Recombinant Human CD70 protein, His-Avi-Flag-tagged, Biotinylated	HEK293	His&FLAG&Avi	Ser 52-Pro 193	Inquiry
Human	CD70-5373H	Recombinant Human CD70 protein, His-tagged	Yeast	His	39-193	Inquiry
Human	CD70-375HFL	Active Recombinant Full Length Human CD70 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	CD70-891HAF488	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	Gln39-Pro193	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-514H	Recombinant Human CD70 Protein (Gln39-Pro193), N-hFc and C-6×His-tagged	HEK293	His&Fc	Gln39-Pro193	Inquiry
Human	CD70-639AF555	Recombinant Human CD70 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	413	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD70-515H	Recombinant Human CD70 Protein (Gln39-Pro193), N-mFc and C-6×His-tagged	HEK293	His&mFc	Gln39-Pro193	Inquiry
Human	CD70-5365H	Recombinant Human CD70 Protein (Gln39-Pro193), N-Fc tagged	Mammalian cells	Fc	Gln39-Pro193	Inquiry
Human	CD70-324H	Active Recombinant Human CD70 Protein (Gln39-Pro193), N-His tagged, Animal-free, Carrier-free	E.coli	His	Gln39-Pro193	Inquiry
Mouse	CD70-3105M	Recombinant Mouse CD70 Protein	Mammalian Cell	His		Inquiry
Mouse	Cd70-6723M	Recombinant Mouse Cd70 protein, His-tagged	E.coli	His	Leu64~Trp192	Inquiry
Mouse	Cd70-972M	Active Recombinant Mouse Cd70 protein(Gln47-Pro159), mFc-tagged	HEK293	mFc	Gln47-Pro159	$461 / 50µg
Mouse	Cd70-972MF	Recombinant Mouse Cd70 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	385	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Cd70-972MA	Recombinant Mouse Cd70 protein, Fc-tagged, APC labeled	HEK293	Fc		Inquiry
Mouse	Cd70-87M	Active Recombinant Mouse Cd70 Protein (Gln47-Pro195), N-His tagged, Animal-free, Carrier-free	E.coli	His	Gln47-Pro195	Inquiry
Mouse	CD70-329M	Recombinant Mouse CD70 protein (active trimer)(HPLC-verified), His-tagged	HEK293	His	149	$798 / 100µg
Mouse	Cd70-972MAF647	Recombinant Mouse Cd70 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	385	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	CD70-330M	Recombinant Mouse CD70 protein, Mouse IgG2a Fc-tagged, low endotoxin	HEK293	mIgG2a	149	$786 / 100µg
Mouse	Cd70-972MAF555	Recombinant Mouse Cd70 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	385	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	CD70-1467M-B	Recombinant Mouse CD70 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Cd70-972MP	Recombinant Mouse Cd70 protein, Fc-tagged, R-PE labeled	HEK293	Fc		Inquiry
Mouse	Cd70-2065M	Recombinant Mouse Cd70 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	CD70-2987M	Active Recombinant Mouse CD70 protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Gln 47-Pro 195	Inquiry
Mouse	CD70-1467M	Recombinant Mouse CD70 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	CD70-2988M	Active Recombinant Mouse CD70 protein, His-tagged	HEK293	His	Gln 47-Pro 195	Inquiry
Mouse	CD70-2989M	Active Recombinant Mouse CD70 protein, mFc-tagged	HEK293	mFc	Gln 47-Pro 195	Inquiry
Mouse	Cd70-972MAF488	Recombinant Mouse Cd70 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	385	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730R	Active Recombinant Rat Cd70 protein, hFc-tagged	HEK293	Fc	Gln46-Pro195	$498 / 50µg
Rat	Cd70-8731R	Active Recombinant Rat Cd70 protein, His-tagged	HEK293	His	Gln46-Pro195	$461 / 20µg
Rat	CD70-1303RCL	Recombinant Rat CD70 cell lysate	Human Cell	Non		Inquiry
Rat	Cd70-8730RF	Recombinant Rat Cd70 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	410	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730RA	Recombinant Rat Cd70 protein, Fc-tagged, APC labeled	HEK293	Fc		Inquiry
Rat	Cd70-8731RAF488	Recombinant Rat Cd70 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	170	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8731RAF647	Recombinant Rat Cd70 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	170	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730RAF555	Recombinant Rat Cd70 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	410	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730RAF647	Recombinant Rat Cd70 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	410	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8731RF	Recombinant Rat Cd70 Protein, His-tagged, FITC conjugated	HEK293	His	170	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730RAF488	Recombinant Rat Cd70 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	410	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd70-8730RP	Recombinant Rat Cd70 protein, Fc-tagged, R-PE labeled	HEK293	Fc		Inquiry
Rat	Cd70-8731RAF555	Recombinant Rat Cd70 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	170	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rhesus monkey	CD70-1804R	Recombinant Rhesus Monkey CD70 Protein	HEK293	Non	38-194	Inquiry
Rhesus monkey	CD70-1805R	Recombinant Rhesus Monkey CD70 Protein, hIgG1-tagged	HEK293	Fc	38-194	Inquiry
Rhesus monkey	CD70-1806R	Recombinant Rhesus Monkey CD70 Protein, hIgG4-tagged	HEK293	hIgG4	38-194	Inquiry
Rhesus Monkey	CD70-01H	Recombinant Rhesus Monkey CD70 Protein, his-tagged	HEK293	His	157	Inquiry
Cynomolgus	CD70-105C	Recombinant Cynomolgus CD70 protein, His-tagged	HEK293	His	Gln39-Pro194	$298 / 5μg $398 / 10μg $898 / 25μg
Mus musculus (Mouse)	RFL17124MF	Recombinant Full Length Mouse Cd70 Antigen(Cd70) Protein, His-Tagged	E.coli expression system	His	Full Length (1-195)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CD70 involved in several pathways and played different roles in them. We selected most pathways CD70 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD70 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	TGFB2;TNFSF13B;LEP;IFNA2;PDGFAB;GM2506;IL23R;CCL20;MPL

CD70 has several biochemical functions, for example, cytokine activity, protease binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD70 itself. We selected most functions CD70 had, and list some proteins which have the same functions with CD70. You can find most of the proteins on our site.

Function	Related Protein
cytokine activity	INHBB;Kitl;SCG2;WNT5A;IL36G;TNFSF4;TNFRSF11B;CMTM2;IL6
protease binding	ELANE;TNFAIP3;NDUFS7;ADAM8A;NFRKB;DVL3;SERPINA1E;SERPINC1;DPP4
protein binding	S100A6;ADAMTS5;HHIP;ICAM3;TMEM79;SORL1;DUT;CRYBA1;CEP170L
receptor binding	Fgf15;Ren1;LHB;PLXNC1;SRMS;WNT7A;FRK;RARA;INHA
tumor necrosis factor receptor binding	TNFSF4;LTA;TNFSF10L3;Fasl;TNF;TRAF2;TRADD;TRAF1;TNFB

CD70 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD70 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD70.

Gene Family

Research Area

Cancer Drug Targets

CAR-T Cell Therapy Targets

Immune Checkpoints

Co-stimulatory TNF Superfamily Molecules

Gamma Delta T Cells

CD Antigen (Helper T Cells)

Tumor Necrosis Factor (TNF)

Co-stimulatory Molecules

Convers, KD; Kariuki, BM; et al. Decreased CD5(-)CD19(+)CD27(+)CD43(+)CD70(-) B-Cell Subpopulation in Children with Specific Antibody Deficiency. PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY 28:27-31(2015).

Tannir, NM; Forero-Torres, A; et al. Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma. INVESTIGATIONAL NEW DRUGS 32:1246-1257(2014).

Reviews
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Customer Reviews (3)

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Reviews

05/31/2021

Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

04/23/2019

the manufacturer's support is crucial for researchers using CD70 protein in trials.

03/07/2017

These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

Q&As (5)

Ask a question

What are some potential CD70-targeted therapies for cancer? 04/29/2023

Antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) T-cell therapies are being developed to target CD70 in cancer.

How can CD70-targeted therapies improve cancer treatment outcomes? 05/03/2022

CD70-targeted therapies can enhance the body's immune response against cancer cells and potentially lead to more effective treatments.

In which hematological malignancies is CD70 expression frequently observed? 04/08/2021

CD70 expression is often observed in Hodgkin's lymphoma and certain types of T-cell lymphomas.

Are there any challenges in developing CD70-targeted therapies for cancer? 03/14/2020

Challenges include potential toxicities and finding the right balance to target CD70 effectively without harming normal immune functions.

Are there clinical trials involving CD70-targeted therapies for cancer treatment? 11/14/2018

Yes, there are ongoing clinical trials exploring CD70-targeted therapies for various cancer types.

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