Recombinant Human CD86 Protein, C-His-tagged

• Cat.No.: CD86-186H
• Product Overview: Recombinant Human CD86 Protein with C-His tag was expressed in E. coli.

Specification

• Description: CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation. CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions. Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~25 kDa
• AA Sequence: APLKIQAYFNETADLPCQFANSQNQ SLSELVVFWQDQENLVLNEVYLGKE KFDSVHSKYMGRTSFDSDSWTLRLH NLQIKDKGLYQCIIHHKKPTGMIRI HQMNSELSVLANFSQPEIVPISNIT ENVYINLTCSSIHGYPEPKKMSVLL RTKNSTIEYDGVMQKSQDNVTELYD VSISLSVSFPDVTSNMTIFCILETD KTRLLSSPFSIELEDPQPPPDHIP
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CD86 CD86 molecule [ Homo sapiens (human) ]
• Official Symbol: CD86
• Synonyms: CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413
• Gene ID: 942
• mRNA Refseq: NM_001206924
• Protein Refseq: NP_001193853
• MIM: 601020
• UniProt ID: P42081