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Recombinant Human CNTF Protein, His-tagged

Cat.No.: CNTF-2013H
Product Overview: Recombinant Human CNTF Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Met200) of human CNTF (Accession #NP_000605.1) fused with a 6×His tag at the C-terminus.
Description: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Source: E. coli
Species: Human
Tag : His
Form: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
Protein length: Met1-Met200
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: > 90% as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: CNTF ciliary neurotrophic factor [ Homo sapiens ]
Official Symbol: CNTF
Synonyms: CNTF; ciliary neurotrophic factor; HCNTF;
Gene ID: 1270
mRNA Refseq: NM_000614
Protein Refseq: NP_000605
MIM: 118945
UniProt ID: P26441

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