CNTF
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Official Full Name
ciliary neurotrophic factor
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Overview
Ciliary neurotrophic factor (CNTF); is a cytokine1 that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.2 With these abilities, CNTF has implications for Parkinson's disease and -
Synonyms
CNTF; ciliary neurotrophic factor; HCNTF;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- His(C
- ter)
- His|S
- His|T7
- MYC
- DDK
- Myc|DDK
- N/A
- N
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- CNTF Related Gene Family
- CNTF Related Research Area
CNTF involved in several pathways and played different roles in them. We selected most pathways CNTF participated on our site, such as Cytokine-cytokine receptor interaction, Delta-Notch Signaling Pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cytokine-cytokine receptor interaction | CXCR4A;KITA;CXCL8B.3;CSF1RA;CLCF1;IFNA4;CSF1;TP-1;CXCL13 |
Delta-Notch Signaling Pathway | ADAM10A;CNTF;ZFPM1;MAGEA1;YY1;SMAD3B;HIVEP3;JAG2;SAP30 |
Jak-STAT signaling pathway | IFNAR1;TP-1;IL12RB1;PIAS4;STAT6;IL2RGB;PIK3R3B;IL6R;IFNA14 |
CNTF has several biochemical functions, for example, ciliary neurotrophic factor receptor binding, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTF itself. We selected most functions CNTF had, and list some proteins which have the same functions with CNTF. You can find most of the proteins on our site.
Function | Related Protein |
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ciliary neurotrophic factor receptor binding | LIFR;Ctf2;CLCF1;IL6ST;CNTF |
growth factor activity | IL34;NOV;GDF10;BMP7A;RABEP1;CECR1;MDK;CXCL1;Il2 |
interleukin-6 receptor binding | ADAM17;ERAP1;IL6;PYCARD;CNTF |
protein binding | TXNDC11;DNAL4;THAP11;NFKBIE;OLIG1;MAZ;ODF1;C1orf65;DDX18 |
CNTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTF here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTF.
TRIP6; KRT40; IL6ST; LIFR; STK16; VHL; EIF3E; ICA1; EXT1; EXT2
- Q&As
- Reviews
Q&As (7)
Ask a questionCNTF plays a crucial role in regulating glial cell function. It can modulate astrocyte and oligodendrocyte differentiation, promote myelination, and regulate the release of neurotrophic factors from glial cells. CNTF also influences glial cell-mediated immune responses and their interaction with neurons in various pathological conditions.
CNTF activates multiple signaling pathways, including JAK/STAT, PI3K/AKT, and MAPK/ERK, in both neurons and glial cells. These pathways play crucial roles in regulating gene expression, cell survival, differentiation, and synaptic plasticity.
CNTF plays a significant role in modulating neuroinflammatory responses. It can regulate the activation and function of microglia and astrocytes, leading to the production of pro-inflammatory or anti-inflammatory factors. CNTF also influences the recruitment and activation of immune cells in the central nervous system.
CNTF has been shown to modulate synaptic plasticity, which underlies learning and memory processes. It promotes the formation and stabilization of synapses, regulates neurotransmitter release, and influences synaptic strength and plasticity through its interaction with specific receptors and downstream signaling molecules.
Developing CNTF-based therapies faces challenges such as the need for targeted delivery to specific brain regions, potential side effects due to systemic administration, and the need to optimize dosing and treatment regimens. Additionally, understanding the precise mechanisms of CNTF action and identifying suitable patient populations for treatment are important considerations.
CNTF exerts neuroprotective effects by promoting neuronal survival and regeneration through the activation of various intracellular signaling pathways. It enhances the expression of neurotrophic factors, regulates apoptosis-related genes, and stimulates axonal outgrowth and synaptic remodeling.
CNTF shows promise as a potential therapeutic approach for neurodegenerative diseases, such as amyotrophic lateral sclerosis and retinal degeneration. Its neuroprotective and neurotrophic effects make it a potential candidate for promoting neuronal survival, preventing neurodegeneration, and improving functional recovery in these conditions.
Customer Reviews (3)
Write a reviewIt is highly durable and meets the requirements for long-term experiments.
A trusted aide, this reagent is instrumental on the path of scientific inquiry.
Employing this protein reagent allows me to obtain precise structural information in protein interaction studies, offering critical insights for a deeper understanding of protein function.
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