CNTF

  • Official Full Name

    ciliary neurotrophic factor

  • Overview

    Ciliary neurotrophic factor (CNTF); is a cytokine1 that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.2 With these abilities, CNTF has implications for Parkinson's disease and
  • Synonyms

    CNTF; ciliary neurotrophic factor; HCNTF;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His(C
  • ter)
  • His|S
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CNTF-11409H Recombinant Human CNTF, GST-tagged E.coli GST
Human CNTF-1606H Recombinant Human CNTF Protein, GST-tagged Wheat Germ GST
Human CNTF-02H Recombinant Human Ciliary Neurotrophic Factor E.coli N/A
Human CNTF-249H Recombinant Human CNTF, StrepII-tagged Human Cell Strep II
Human CNTF-566H Active Recombinant Human CNTF protein, His-tagged E.coli His
Human CNTF-36H Recombinant Human CNTF protein E.coli N/A
Human CNTF-26842TH Recombinant Human CNTF, His-tagged E.coli His
Human CNTF-06H Recombinant Human CNTF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CNTF-08H Recombinant Human Ciliary Neurotrophic Factor, His-tagged E.coli His
Human CNTF-161H Recombinant Human CNTF protein, His/S-tagged E.coli His/S
Human CNTF-26841TH Recombinant Human CNTF E.coli N/A
Human CNTF-376HCL Recombinant Human CNTF cell lysate N/A
Human CNTF-2013H Recombinant Human CNTF Protein, His-tagged E.coli His
Human CNTF-139H Recombinant Human Ciliary Neurotrophic Factor (rDNA derived) Reference standard E.coli N/A
Human CNTF-132C Active Recombinant Human CNTF Protein (199 aa) E.coli
Human CNTF-1966HF Recombinant Full Length Human CNTF Protein, GST-tagged In Vitro Cell Free System GST
Human CNTF-020H Active Recombinant Human CNTF Protein E. coli
Human CNTF-2212H Recombinant Human CNTF protein, His&Myc-tagged Yeast His&Myc
Human CNTF-2587H Active Recombinant Human CNTF protein, His-tagged E.coli His
Human CNTF-43H Recombinant Active Human CNTF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human CNTF-2711H Recombinant Human CNTF protein, His-tagged E.coli His
Human CNTF-39H Active Recombinant Human CNTF Protein E.coli
Human CNTF-16H Active Recombinant Human CNTF Protein (Met1-Met200), C-His tagged, Animal-free, Carrier-free E.coli C-His
Human CNTF-148H Recombinant Human CNTF Protein E.coli
Human CNTF-192C Active Recombinant Human CNTF Protein HEK293
Human CNTF-435C Active Recombinant Human CNTF Protein (199 aa) E.coli
Human CNTF-26839TH Native Human CNTF E.coli N/A
Mouse Cntf-490M Active Recombinant Mouse Cntf protein, His-tagged E.coli His
Mouse CNTF-995M Active Recombinant Mouse CNTF Protein, His-tagged E.coli His
Mouse Cntf-01M Active GMP Recombinant Mouse Cntf Protein, His-Tagged E.coli His
Mouse Cntf-160M Recombinant Mouse Cntf protein, His/S-tagged E.coli His/S
Mouse CNTF-3682M Recombinant Mouse CNTF Protein Mammalian Cell His
Mouse Cntf-565M Recombinant Mouse Cntf protein E.coli N/A
Mouse Cntf-44M Recombinant Active Mouse CNTF Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Cntf-434C Active Recombinant Mouse Cntf Protein (197 aa) E.coli
Mouse CNTF-1827M Recombinant Mouse CNTF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CNTF-1827M-B Recombinant Mouse CNTF Protein Pre-coupled Magnetic Beads HEK293
Mouse Cntf-17M Active Recombinant Mouse Cntf Protein (Met1-Met198), C-His tagged, Animal-free, Carrier-free E.coli C-His
Mouse CNTF-1236M Recombinant Mouse CNTF protein, His-tagged E.coli His
Mouse CNTF-3229M Recombinant Mouse CNTF protein, His-tagged HEK293 His
Mouse Cntf-913M Recombinant Mouse Cntf Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cntf-807M Recombinant Mouse Cntf Protein, His-tagged HEK293F N-His
Rat Cntf-296R Recombinant Rat Ciliary Neurotrophic Factor E.coli N/A
Rat Cntf-594R Recombinant Rat Cntf protein E.coli N/A
Rat Cntf-374R Recombinant Rat Cntf Protein, His-tagged E.coli His
Rat Cntf-159R Recombinant Rat Cntf protein, His/S-tagged E.coli His/S
Rat CNTF-1500R Recombinant Rat CNTF Protein Mammalian Cell His
Rat Cntf-579R Recombinant Rat Cntf, None tagged E.coli N/A
Rat Cntf-433C Active Recombinant Rat Cntf Protein (199 aa) E.coli
Rat CNTF-1157R Recombinant Rat CNTF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CNTF-1157R-B Recombinant Rat CNTF Protein Pre-coupled Magnetic Beads HEK293
Rabbit CNTF-588R Recombinant Rabbit CNTF protein, His & T7-tagged E.coli His/T7
Zebrafish CNTF-7368Z Recombinant Zebrafish CNTF Mammalian Cell His
Pig CNTF-587P Recombinant Pig CNTF protein, His & T7-tagged E.coli His/T7
Chicken CNTF-7041C Recombinant Chicken CNTF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CNTF Related Gene Family
  • CNTF Related Research Area

CNTF involved in several pathways and played different roles in them. We selected most pathways CNTF participated on our site, such as Cytokine-cytokine receptor interaction, Delta-Notch Signaling Pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNA7;VEGFAA;IFNA21;PF4;TNFB;CCL24;BMPR2B;VEGFC;KDRL
Delta-Notch Signaling PathwayCNTFR;SMAD3B;NOV;RING1;HES6;JAG2;HEY1;YY1;MAGEA1
Jak-STAT signaling pathwaySOCS1A;IL11RA2;GFAP;Il4ra;STAT5B;GM2002;IL22RA1;IL21R.1;IL2RGB

CNTF has several biochemical functions, for example, ciliary neurotrophic factor receptor binding, growth factor activity, interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTF itself. We selected most functions CNTF had, and list some proteins which have the same functions with CNTF. You can find most of the proteins on our site.

Function Related Protein
ciliary neurotrophic factor receptor bindingLIFR;CLCF1;IL6ST;Ctf2;CNTF
growth factor activityPDGFA;TGFB2;PRL2C2;HDGF;BMP10;IL9;GDF15;CD320;TGFA
interleukin-6 receptor bindingADAM17;ERAP1;CNTF;PYCARD;IL6
protein bindingDRD2;NOV;NUF2;NFS1;TCEANC;ANKFY1;KRR1;ASGR1;ROS1

CNTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTF here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTF.

TRIP6; KRT40; IL6ST; LIFR; STK16; VHL; EIF3E; ICA1; EXT1; EXT2

IL
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CNTF affect glial cell function? 08/18/2021

CNTF plays a crucial role in regulating glial cell function. It can modulate astrocyte and oligodendrocyte differentiation, promote myelination, and regulate the release of neurotrophic factors from glial cells. CNTF also influences glial cell-mediated immune responses and their interaction with neurons in various pathological conditions.

What are the signaling pathways activated by CNTF in neurons and glial cells? 11/28/2020

CNTF activates multiple signaling pathways, including JAK/STAT, PI3K/AKT, and MAPK/ERK, in both neurons and glial cells. These pathways play crucial roles in regulating gene expression, cell survival, differentiation, and synaptic plasticity.

What is the role of CNTF in neuroinflammation? 09/08/2019

CNTF plays a significant role in modulating neuroinflammatory responses. It can regulate the activation and function of microglia and astrocytes, leading to the production of pro-inflammatory or anti-inflammatory factors. CNTF also influences the recruitment and activation of immune cells in the central nervous system.

How does CNTF affect synaptic plasticity? 10/22/2016

CNTF has been shown to modulate synaptic plasticity, which underlies learning and memory processes. It promotes the formation and stabilization of synapses, regulates neurotransmitter release, and influences synaptic strength and plasticity through its interaction with specific receptors and downstream signaling molecules.

What are the challenges in developing CNTF-based therapies? 10/16/2016

Developing CNTF-based therapies faces challenges such as the need for targeted delivery to specific brain regions, potential side effects due to systemic administration, and the need to optimize dosing and treatment regimens. Additionally, understanding the precise mechanisms of CNTF action and identifying suitable patient populations for treatment are important considerations.

How does CNTF promote neuronal survival and regeneration? 04/14/2016

CNTF exerts neuroprotective effects by promoting neuronal survival and regeneration through the activation of various intracellular signaling pathways. It enhances the expression of neurotrophic factors, regulates apoptosis-related genes, and stimulates axonal outgrowth and synaptic remodeling.

Can CNTF be a potential therapeutic approach for neurodegenerative diseases? 02/07/2016

CNTF shows promise as a potential therapeutic approach for neurodegenerative diseases, such as amyotrophic lateral sclerosis and retinal degeneration. Its neuroprotective and neurotrophic effects make it a potential candidate for promoting neuronal survival, preventing neurodegeneration, and improving functional recovery in these conditions.

Customer Reviews (3)

Write a review
Reviews
03/04/2020

    It is highly durable and meets the requirements for long-term experiments.

    06/02/2017

      A trusted aide, this reagent is instrumental on the path of scientific inquiry.

      09/01/2016

        Employing this protein reagent allows me to obtain precise structural information in protein interaction studies, offering critical insights for a deeper understanding of protein function.

        Ask a Question for All CNTF Products

        Required fields are marked with *

        My Review for All CNTF Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends