Recombinant Human Colony TtimulatingFactor 3 Receptor (Granulocyte)

• Cat.No.: CSF3R-3120H
• Product Overview: Recombinant Human CSF3R (extracellular domain, Met 1-Pro 621) with five aminio acids at the C-terminus, was expressed in Human cells.

Specification

• Cat. No.: CSF3R-3120H
• Description: Granulocyte Colony Stimulating Factor Receptor (G-CSFR) which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. G-CSFR mediates the specific effect of G-CSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis.
• Purity: >95% as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu 25
• Molecular Mass: The mature recombinant human G-CSFR consists of 63 amino acids and predicts a molecular mass of 69.0 KDa. As a result of glycosylation, the apparent molecular mass of rhG-CSFR is approximately 90-95KDa in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH 7.4 . Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
• Synonyms: colony stimulating factor 3 receptor (granulocyte); GCSFR; colony stimulating factor 3 receptor; antigenOTTHUMP00000009703; CSF3R; antigenOTTHUMP00000009704; CD114; antigenOTTHUMP00000009705; granulocyte colony stimulating factor receptor
• Gene ID: 1441
• mRNA Refseq: NM_000760
• Protein Refseq: NP_000751
• MIM: 138971
• UniProt ID: Q99062
• Chromosome Location: 1p35-p34.3
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer
• Function: cytokine receptor activity; otein binding; receptor activity