Recombinant Human CSE1L Protein (1-200 aa), His-SUMO-tagged
Cat.No. : | CSE1L-2732H |
Product Overview : | Recombinant Human CSE1L Protein (1-200 aa) is produced by in vitro E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cell Biology. Protein Description: Partial. |
- Specification
- Gene Information
- Related Products
Description : | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
Source : | E. coli Cell Free |
Species : | Human |
Tag : | His-SUMO |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 39.1 kDa |
Protein length : | 1-200 aa |
AA Sequence : | MELSDANLQTLTEYLKKTLDPDPAI RRPAEKFLESVEGNQNYPLLLLTLL EKSQDNVIKVCASVTFKNYIKRNWR IVEDEPNKICEADRVAIKANIVHLM LSSPEQIQKQLSDAISIIGREDFPQ KWPDLLTEMVNRFQSGDFHVINGVL RTAHSLFKRYRHEFKSNELWTEIKL VLDAFALPLTNLFKATIELCSTHAN |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ] |
Official Symbol : | CSE1L |
Synonyms : | CSE1L; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; MGC117283; MGC130036; MGC130037; |
Gene ID : | 1434 |
mRNA Refseq : | NM_001256135 |
Protein Refseq : | NP_001243064 |
MIM : | 601342 |
UniProt ID : | P55060 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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