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Recombinant Human DCN Protein (Met1-Lys359)

Cat.No. : DCN-356H
Product Overview : Recombinant Human DCN Protein (NP_001911.1) (Met1-Lys359) was produced by HEK293 Cells expression system.
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Description : Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Source : HEK293
Species : Human
Predicted N Terminal : Gly 17
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human DCN consists of 343 amino acids and predicts a molecular mass of 38 kDa.
Protein length : Met1-Lys359
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : DCN decorin [ Homo sapiens ]
Official Symbol : DCN
Synonyms : DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; CSCD; PG40; PGII; PGS2;
Gene ID : 1634
mRNA Refseq : NM_001920
Protein Refseq : NP_001911
MIM : 125255
UniProt ID : P07585

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the effect of targeted DCN delivery on tumor growth in a mouse model of breast cancer? 07/10/2022

Targeted DCN delivery in breast cancer models reduces tumor growth.

How does DCN modulate TGF-β signaling at the molecular level? 05/06/2022

DCN modulates TGF-β signaling, affecting fibrosis and cancer development.

How do variations in the glycosaminoglycan chains attached to DCN influence its interaction with growth factors? 12/11/2021

Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.

What are the cellular and molecular consequences of DCN gene silencing in fibroblasts? 12/07/2021

DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.

How do mechanical forces influence the function and localization of DCN in the cardiac extracellular matrix? 04/30/2021

Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.

Which proteins are differentially expressed in cells overexpressing DCN compared to control cells? 10/14/2019

Overexpression of DCN changes protein expression related to cell growth and matrix interactions.

What is the detailed three-dimensional structure of DCN when bound to collagen? 07/27/2018

DCN bound to collagen reveals binding sites essential for collagen structure.

Customer Reviews (3)

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Reviews
03/11/2020

    Excellent support for protein purification. Highly recommend this service.

    11/01/2019

      Efficient protein expression, quick turnaround time, and reliable results.

      10/14/2019

        Outstanding antibody validation; trustworthy for protein-protein interaction studies.

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