Recombinant Human DCN Protein (Met1-Lys359)
Cat.No. : | DCN-356H |
Product Overview : | Recombinant Human DCN Protein (NP_001911.1) (Met1-Lys359) was produced by HEK293 Cells expression system. |
- Specification
- Gene Information
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Description : | Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles. |
Source : | HEK293 |
Species : | Human |
Predicted N Terminal : | Gly 17 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human DCN consists of 343 amino acids and predicts a molecular mass of 38 kDa. |
Protein length : | Met1-Lys359 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | DCN decorin [ Homo sapiens ] |
Official Symbol : | DCN |
Synonyms : | DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; CSCD; PG40; PGII; PGS2; |
Gene ID : | 1634 |
mRNA Refseq : | NM_001920 |
Protein Refseq : | NP_001911 |
MIM : | 125255 |
UniProt ID : | P07585 |
Products Types
◆ Recombinant Protein | ||
DCN-450M | Recombinant Mouse DCN Protein (35-354 aa), His-SUMO-tagged | +Inquiry |
DCN-1377M | Recombinant Mouse DCN Protein (35-354 aa), His-tagged | +Inquiry |
DCN-73H | Recombinant Human DCN protein(Asp31-Lys359), hFc-tagged | +Inquiry |
DCN-815H | Recombinant Human DCN Protein, His-tagged | +Inquiry |
DCN-1455R | Recombinant Rat DCN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DCN-2274HCL | Recombinant Human DCN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTargeted DCN delivery in breast cancer models reduces tumor growth.
DCN modulates TGF-β signaling, affecting fibrosis and cancer development.
Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.
DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.
Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.
Overexpression of DCN changes protein expression related to cell growth and matrix interactions.
DCN bound to collagen reveals binding sites essential for collagen structure.
Customer Reviews (3)
Write a reviewExcellent support for protein purification. Highly recommend this service.
Efficient protein expression, quick turnaround time, and reliable results.
Outstanding antibody validation; trustworthy for protein-protein interaction studies.
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