Recombinant Rat Dhodh Full Length Transmembrane protein, His-tagged

• Cat.No.: Dhodh-902R
• Product Overview: Recombinant Rat Dhodh protein(Q63707)(1-395aa), fused with N-terminal His tag, was expressed in in vitro E. coli expression system.

Specification

• Source: In vitro E. coli expression system
• Species: Rat
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 44.2 kDa
• Protein Length: 1-395aa
• AA Sequence: MAWRQLRKRALDAVIILGGGGLLFT SYLTATGDDHFYAEYLMPGLQRLLD PESAHRLAVRVTSLGLLPRATFQDS DMLEVKVLGHKFRNPVGIAAGFDKN GEAVDGLYKLGFGFVEVGSVTPQPQ EGNPRPRVFRLPEDQAVINRYGFNS HGLSVVEHRLRARQQKQAQLTADGL PLGINLGKNKTSEDAAADYAEGVRT LGPLADYLVVNVSSPNTAGLRSLQG KTELRHLLSKVLQERDALKGTRKPA VLVKIAPDLTAQDKEDIASVARELG IDGLIVTNTTVSRPVGLQGALRSET GGLSGKPLRDLSTQTIREMYALTQG RIPIIGVGGVSSGQDALEKIQAGAS LVQLYTALIFLGPPVVVRVKRELEA LLKERGFTTVTDAIGADHRR
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: Dhodh dihydroorotate dehydrogenase (quinone) [ Rattus norvegicus ]
• Official Symbol: Dhodh
• Synonyms: DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase (quinone), mitochondrial; DHOdehase; dihydroorotate oxidase; dihydroorotate dehydrogenase, mitochondrial
• Gene ID: 65156
• mRNA Refseq: NM_001008553
• Protein Refseq: NP_001008553

Reviews

07/29/2020

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11/03/2017

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05/05/2017

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Q&As

How does DHODH contribute to pyrimidine biosynthesis?

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism?

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway?

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth?

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis?

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases?

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment?

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.