"DICER1" Related Products

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Recombinant Human DICER1 protein, MYC/DDK-tagged

Cat.No.: DICER1-33H
Product Overview: Recombinant Human DICER1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Source: HEK293
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 218.5 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: DICER1 dicer 1, ribonuclease type III [ Homo sapiens ]
Official Symbol: DICER1
Synonyms: DICER1; dicer 1, ribonuclease type III; Dicer1, Dcr 1 homolog (Drosophila); endoribonuclease Dicer; Dicer; dicer 1; double stranded RNA specific endoribonuclease; HERNA; K12H4.8 LIKE; KIAA0928; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR1; MNG1;
Gene ID: 23405
mRNA Refseq: NM_177438
Protein Refseq: NP_803187
MIM: 606241
UniProt ID: Q9UPY3
Chromosome Location: 14q32.2
Pathway: Gene expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem; mRNA processing, organism-specific biosystem;
Function: ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; endonuclease activity; helicase activity; hydrolase activity; metal ion binding; miRNA binding; nucleotide binding; protein binding; ribonuclease III activity; ribonuclease III activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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