Recombinant Human DSC2 Protein, GST-tagged

• Cat.No.: DSC2-2878H
• Product Overview: Human DSC2 full-length ORF ( NP_004940.1, 1 a.a. - 847 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 120.2 kDa
• AA Sequence: MEAARPSGSWNGALCRLLLLTLAIL IFASDACKNVTLHVPSKLDAEKLVG RVNLKECFTAANLIHSSDPDFQILE DGSVYTTNTILLSSEKRSFTILLSN TENQEKKKIFVFLEHQTKVLKKRHT KEKVLRRAKRRWAPIPCSMLENSLG PFPLFLQQVQSDTAQNYTIYYSIRG PGVDQEPRNLFYVERDTGNLYCTRP VDREQYESFEIIAFATTPDGYTPEL PLPLIIKIEDENDNYPIFTEETYTF TIFENCRVGTTVGQVCATDKDEPDT MHTRLKYSIIGQVPPSPTLFSMHPT TGVITTTSSQLDRELIDKYQLKIKV QDMDGQYFGLQTTSTCIINIDDVND HLPTFTRTSYVTSVEENTVDVEILR VTVEDKDLVNTANWRANYTILKGNE NGNFKIVTDAKTNEGVLCVVKPLNY EEKQQMILQIGVVNEAPFSREASPR SAMSTATVTVNVEDQDEGPECNPPI QTVRMKENAEVGTTSNGYKAYDPET RSSSGIRYKKLTDPTGWVTIDENTG SIKVFRSLDREAETIKNGIYNITVL ASDQGGRTCTGTLGIILQDVNDNSP FIPKKTVIICKPTMSSAEIVAVDPD EPIHGPPFDFSLESSTSEVQRMWRL KAINDTAARLSYQNDPPFGSYVVPI TVRDRLGMSSVTSLDVTLCDCITEN DCTHRVDPRIGGGGVQLGKWAILAI LLGIALLFCILFTLVCGASGTSKQP KVIPDDLAQQNLIVSNTEAPGDDKV YSANGFTTQTVGASAQGVCGTVGSG IKNGGQETIEMVKGGHQTSESCRGA GHHHTLDSCRGGHTEVDNCRYTYSE WHSFTQPRLGEESIRGHTLIKN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DSC2 desmocollin 2 [ Homo sapiens ]
• Official Symbol: DSC2
• Synonyms: DSC2; desmocollin 2; DSC3; desmocollin-2; CDHF2; cadherin family member 2; desmosomal glycoprotein II; desmosomal glycoprotein III; desmosomal glycoprotein II/III; DG2; ARVD11; DGII/III; DKFZp686I11137
• Gene ID: 1824
• mRNA Refseq: NM_004949
• Protein Refseq: NP_004940
• MIM: 125645
• UniProt ID: Q02487