Description : |
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
93.77 kDa |
AA Sequence : |
MEAARPSGSWNGALCRLLLLTLAIL IFASDACKNVTLHVPSKLDAEKLVG RVNLKECFTAANLIHSSDPDFQILE DGSVYTTNTILLSSEKRSFTILLSN TENQEKKKIFVFLEHQTKVLKKRHT KEKVLRRAKRRWAPIPCSMLENSLG PFPLFLQQVQSDTAQNYTIYYSIRG PGVDQEPRNLFYVERDTGNLYCTRP VDREQYESFEIIAFATTPDGYTPEL PLPLIIKIEDENDNYPIFTEETYTF TIFENCRVGTTVGQVCATDKDEPDT MHTRLKYSIIGQVPPSPTLFSMHPT TGVITTTSSQLDRELIDKYQLKIKV QDMDGQYFGLQTTSTCIINIDDVND HLPTFTRTSYVTSVEENTVDVEILR VTVEDKDLVNTANWRANYTILKGNE NGNFKIVTDAKTNEGVLCVVKPLNY EEKQQMILQIGVVNEAPFSREASPR SAMSTATVTVNVEDQDEGPECNPPI QTVRMKENAEVGTTSNGYKAYDPET RSSSGIRYKKLTDPTGWVTIDENTG SIKVFRSLDREAETIKNGIYNITVL ASDQGGRTCTGTLGIILQDVNDNSP FIPKKTVIICKPTMSSAEIVAVDPD EPIHGPPFDFSLESSTSEVQRMWRL KAINDTAARLSYQNDPPFGSYVVPI TVRDRLGMSSVTSLDVTLCDCITEN DCTHRVDPRIGGGGVQLGKWAILAI LLGIALLFCILFTLVCGASGTSKQP KVIPDDLAQQNLIVSNTEAPGDDKV YSANGFTTQTVGASAQGVCGTVGSG IKNGGQETIEMVKGGHQTSESCRGA GHHHTLDSCRGGHTEVDNCRYTYSE WHSFTQPRLGEESIRGHTLIKNTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |