Recombinant Human DSG1 Protein, GST-tagged

• Cat.No.: DSG1-2890H
• Product Overview: Human DSG1 full-length ORF ( AAI53002.1, 1 a.a. - 1049 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 142.34 kDa
• AA Sequence: MDWSFFRVVAMLFIFLVVVEVNSEF RIQVRDYNTKNGTIKWHSIRRQKRE WIKFAAACREGEDNSKRNPIAKIHS DCAANQQVTYRISGVGIDQPPYGIF VINQKTGEINITSIVDREVTPFFII YCRALNSMGQDLERPLELRVRVLDI NDNPPVFSMATFAGQIEENSNANTL VMILNATDADEPNNLNSKIAFKIIR QEPSDSPMFIINRNTGEIRTMNNFL DREQYGQYALAVRGSDRDGGADGMS AECECNIKILDVNDNIPYMEQSSYT IEIQENTLNSNLLEIRVIDLDEEFS ANWMAVIFFISGNEGNWFEIEMNER TNVGILKVVKPLDYEAMQSLQLSIG VRNKAEFHHSIMSQYKLKASAISVT VLNVIEGPVFRPGSKTYVVTGNMGS NDKVGDFVATDLDTGRPSTTVRYVM GNNPADLLAVDSRTGKLTLKNKVTK EQYNMLGGKYQGTILSIDDNLQRTC TGTININIQSFGNDDRTNTEPNTKI TTNTGRQESTSSTNYDTSTTSTDSS QVYSSEPGNGAKDLLSDNVHFGPAG IGLLIMGFLVLGLVPFLMICCDCGG APRSAAGFEPVPECSDGAIHSWAVE GPQPEPRDITTVIPQIPPDNANIIE CIDNSGVYTNEYGGREMQDLGGGER MTGFELTEGVKTSGMPEICQEYSGT LRRNSMRECREGGLNMNFMESYFCQ KAYAYADEDEGRPSNDCLLIYDIEG VGSPAGSVGCCSFIGEDLDDSFLDT LGPKFKKLADISLGKESYPDLDPSW PPQSTEPVCLPQETEPVVSGHPPIS PHFGTTTVISESTYPSGPGVLHPKP ILDPLGYGNVTVTESYTTSDTLKPS VHVHDNRPASNVVVTERVVGPISGA DLHGMLEMPDLRDGSNVIVTERVIA PSSSLPTSLTIHHPRESSNVVVTER VIQPTSGMIGSLSMHPELANAHNVI VTERVVSGAGVTGISGTTGISGGIG SSGLVGTSMGAGSGALSGAGISGGG IGLSSLGGTASIGHMRSSSDHHFNQ TIGSASPSTARSRITKYSTVQYSK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
• Official Symbol: DSG1
• Synonyms: DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen; DG1; PPKS1; SPPK1
• Gene ID: 1828
• mRNA Refseq: NM_001942
• Protein Refseq: NP_001933
• MIM: 125670
• UniProt ID: Q02413