Recombinant Human DUSP6 Protein, GST-tagged

• Cat.No.: DUSP6-2945H
• Product Overview: Human DUSP6 full-length ORF ( AAH03143, 1 a.a. - 381 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 67.65 kDa
• AA Sequence: MIDTLRPVPFASEMAISKTVAWLNE QLELGNERLLLMDCRPQELYESSHI ESAINVAIPGIMLRRLQKGNLPVRA LFTRGEDRDRFTRRCGTDTVVLYDE SSSDWNENTGGESLLGLLLKKLKDE GCRAFYLEGGFSKFQAEFSLHCETN LDGSCSSSSPPLPVLGLGGLRISSD SSSDIESDLDRDPNSATDSDGSPLS NSQPSFPVEILPFLYLGCAKDSTNL DVLEEFGIKYILNVTPNLPNLFENA GEFKYKQIPISDHWSQNLSQFFPEA ISFIDEARGKNCGVLVHCLAGISRS VTVTVAYLMQKLNLSMNDAYDIVKM KKSNISPNFNFMGQLLDFERTLGLS SPCDNRVPAQQLYFTTPSNQNVYQV DSLQST
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DUSP6 dual specificity phosphatase 6 [ Homo sapiens ]
• Official Symbol: DUSP6
• Synonyms: DUSP6; dual specificity phosphatase 6; dual specificity protein phosphatase 6; MKP 3; PYST1; MAP kinase phosphatase 3; dual specificity protein phosphatase PYST1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 3; MKP3
• Gene ID: 1848
• mRNA Refseq: NM_001946
• Protein Refseq: NP_001937
• MIM: 602748
• UniProt ID: Q16828